Zogulitsa

Neuroblastoma, khansa ya m'mitsempha yachifundo, ndiye chotupa cholimba cha extracranial mwa ana.Kukulitsa kwa MYCN ndi kuwonjezeka kwa chizindikiro cha BDNF/TrkB ndi mawonekedwe a zotupa zowopsa kwambiri;komabe, ndi ˜25% yokha ya zotupa zowopsa zomwe zimawonetsa izi.Chifukwa chake, kuzindikirika kwa ma biomarker owonjezera ndi zolinga zachipatala ndikofunikira.Monga aminoacylase 1 (ACY1), amino acid deacetylase, ndi chotupa chotupa m'mapapo ang'onoang'ono am'mapapo ndi aimpso cell carcinomas, tidafufuza ngati iwo kapena achibale ena aspartoacylase (ASPA, aminoacylase 2) kapena aminoacylase 3 (ACY3) atha kutumikira. ntchito yofanana mu neuroblastoma.Mawu a aminoacylase adawunikidwa mu TrkB-positive, MYCN-amplified (SMS-KCNR ndi SK-N-BE) ndi TrkB-negative, non-MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y ndi SH-EP) ma cell a neuroblastoma.Aminoacylase iliyonse imawonetsa kusiyanasiyana kwa malo (ie, cytosolic ACY1, ASPA yogwirizana ndi membrane ndi nyukiliya ACY3).Maselo a SK-N-SH akathandizidwa ndi ma neural differentiation agents (mwachitsanzo, retinoic acid ndi cAMP) muzofalitsa zomwe zili ndi 10% seramu, ACY1 ndiyo yokhayo ya aminoacylase yomwe mawu ake adasinthidwa.ASPA idawonetsedwa makamaka m'maselo a SH-EP a sublineage ya glial.ACY3 idawonetsedwa kwambiri mu mizere ya TrkB-positive, MYCN-amplified.Ma aminoacylases atatu onsewa adawonetsedwa mu adrenal gland yamunthu, malo omwe amapezeka ndi neuroblastoma, koma ACY1 ndi ACY3 okha ndi omwe amawonetsa chotupa chachikulu cha neuroblastoma.Kufufuza kwa data ya Bioinformatics pa kupulumuka kwa Kaplan-Meier kunawonetsa kuti mawu apamwamba a ACY3 amayenderana ndi kusazindikira bwino, pomwe kutsika kwa ACY1 kapena ASPA kumayenderana ndi kusazindikira bwino.Deta iyi ikuwonetsa kuti mawu a aminoacylase amasokonekera mu neuroblastoma