Zogulitsa

Cholinga cha kafukufukuyu chinali kuyerekeza mphamvu ya valproate ndi haloperidol pochepetsa mulingo wa chipwirikiti kwa odwala omwe akhudzidwa mu dipatimenti yadzidzidzi.Tidapereka odwala 80 omwe anali okwiya kwambiri kuti alandire mtsempha wa sodium valproate (20 mg/kg) kapena intramuscular haloperidol (5 mg/1 ml).Kusokonezeka kunayesedwa poyambira ndi 30 min pambuyo pa jekeseni yoyamba pogwiritsa ntchito Agitation-Calmness Evaluation Scale (ACES), Positive and Negative Syndrome Scale-Excited Component subscale, ndi Agitated Behavior Scale.Kwa odwala 80 omwe amathandizidwa ndi sodium valproate, kuchuluka kwa ± SD mlingo kunali 1541.5 ± 286 mg (kusiyana 940-2400).Zomwe zimatanthawuza za postintervention ACES ziwerengero kuyambira pachiyambi mpaka 30 min pambuyo jekeseni mankhwala anali 4.73 (SD = 1.93) kwa gulu la valproate ndi 5.45 (SD = 2.09) kwa gulu la haloperidol (P = 0.028).Palibe kusiyana kwakukulu komwe kunawonedwa ponena za kusintha kwapakati pa 30 min pambuyo pa kulowererapo kwa miyeso iwiri yowonjezera yachisokonezo.Ochuluka a odwala omwe ali m'gulu la haloperidol adakumana ndi sedation kwambiri (36.2%, P <0.001) ndi zizindikiro za extrapyramidal (8.7%, P = 0.007) poyerekeza ndi gulu la valproate (2.5% chifukwa cha sedation kwambiri, palibe wodwala zizindikiro za extrapyramidal).Zomwe zapezazi zikusonyeza kuti pochita zachipatala zachipatala chadzidzidzi, valproate yodutsa m'mitsempha imakhala yothandiza ngati haloperidol kuchepetsa kusokonezeka, ndi mbiri yabwino yachitetezo.