Zogulitsa

5,6-Dihydro-3- (4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl) phenyl] -2 (1H) -pyridinone, wotchedwanso DMPHP, ndi heterocyclic pawiri ndi ntchito zosiyanasiyana. mu chemistry yamankhwala ndi kupeza mankhwala.Pano pali kufotokoza kwa ntchito zake m'mawu pafupifupi 300. DMPHP imadziwika ndi mphamvu zake monga choletsa champhamvu komanso chosankha cha ma enzymes ndi zolandilira m'thupi la munthu.Chimodzi mwazofunikira zake ndi gawo la inhibition ya kinase.Kinase ndi ma enzymes omwe amagwira ntchito yofunika kwambiri pamayendedwe amaselo ndipo nthawi zambiri amakhudzidwa ndi matenda osiyanasiyana, kuphatikiza khansa.DMPHP yapezeka kuti imaletsa mwapadera kinase, potero imasokoneza ma cascades osadziwika omwe amathandizira kuti matenda achuluke.Izi zimapangitsa kuti munthu akhale wodalirika pa chitukuko cha mankhwala ochizira matenda osiyanasiyana, kuphatikizapo khansa, kutupa, ndi matenda a mitsempha.Kutupa ndi kuyankha kwachilengedwe kwa thupi ku matenda kapena kuvulala koma kumatha kukhala kwanthawi yayitali ndikuyambitsa matenda osiyanasiyana.DMPHP yawonetsa kuthekera koletsa njira zina zoyambitsa kutupa, kuchepetsa kupanga oyimira pakati otupa.Katunduyu amapanga chida chamtengo wapatali pakupanga mankhwala oletsa kutupa, kuthandizira kuchiza matenda monga nyamakazi ya nyamakazi, kutupa kwamatumbo, ndi asthma.DMPHP yafufuzidwanso chifukwa cha kuthekera kwake ngati mankhwala ochepetsa ululu kapena ochepetsa ululu. .Kupweteka kosatha ndi vuto lalikulu la thanzi, ndipo njira zochiritsira zamakono nthawi zambiri zimakhala ndi malire kapena zotsatira zosafunika.DMPHP yawonetsa zotsatira za analgesic m'maphunziro a preclinical, kuwonetsa kuthekera kwake ngati njira yatsopano yochizira kupweteka.Pogwiritsa ntchito ma receptor enieni ndi ma neurotransmitters omwe amakhudzidwa ndi ululu, DMPHP ikhoza kupereka njira ina yothetsera ululu ndi zotsatira zochepa zomwe zingakhale zochepa.Mitsempha monga matenda a Alzheimer's ndi Parkinson's disease imaphatikizapo njira zovuta komanso kusokoneza ma receptor osiyanasiyana ndi michere mu ubongo.DMPHP yaphunziridwa chifukwa cha kuthekera kwake ngati neuroprotective agent komanso kuthekera kwake kopititsa patsogolo chidziwitso.Poyang'ana zolandilira zenizeni ndi njira zomwe zimakhudzidwa ndi matenda a neurodegenerative, DMPHP imakhala ndi lonjezo ngati chithandizo chamankhwala pazovuta izi. 1-piperidinyl) phenyl] -2 (1H) -pyridinone (DMPHP) ndi gulu losunthika lomwe lingagwiritsidwe ntchito mu kinase inhibition, anti-inflammatory activity, analgesia, ndi neuroprotection.Kutha kwake posankha ma enzyme ndi ma receptor omwe amakhudzidwa ndi njira za matenda kumapangitsa kuti akhale munthu wowoneka bwino wopezeka ndi mankhwala komanso chithandizo chamankhwala.Kufufuza kwina ndi chitukuko kungavumbulutse zogwiritsidwa ntchito zowonjezera ndikukulitsa mawonekedwe ake pazowonetsa zenizeni.