5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 White mpaka kristalo woyera
| Nambala ya Catalog | XD90230 |
| Dzina lazogulitsa | 5-Sulfosalicylic acid dihydrate |
| CAS | 5965-83-3 |
| Molecular Formula | Chithunzi cha C7H10O8S |
| Kulemera kwa Maselo | 254.215 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29182900 |
Mafotokozedwe a Zamalonda
| Sulfate | 5.5% kupitirira |
| Chinyezi | 22% max |
| Maonekedwe | Koyera mpaka koyera koyera |
| Total asidi | 99-104% |
| Kuyesa | 99% |
Polycations amafufuzidwa ngati zonyamulira kuti apereke achire ma nucleic acid.Polycations ndi inert pharmacological ndi ntchito yokhayo yoperekera katundu wochizira.Kafukufukuyu akuwonetsa kaphatikizidwe ka self-immolative polycation (DSS-BEN) yotengera polyamine analogue mankhwala N(1),N(11) -bisethylnorspermine (BENSpm).Polycation idapangidwa kuti izigwira ntchito ngati chonyamulira jini komanso mankhwala omwe amalunjika ku dysregulated polyamine metabolism mu khansa.Pogwiritsa ntchito kuphatikiza kwa NMR ndi HPLC, timatsimikizira kuti self-immolative polycation ikukumana ndi kuwonongeka kwa mankhwala amtundu wa BENSpm.BENSpm yotulutsidwa imachepetsa kuchuluka kwa ma cell a spermidine ndi spermine ndikuwongolera ma enzymes a polyamine catabolic spermine/spermidine N(1) -acetyltransferase (SSAT) ndi spermine oxidase (SMO).Ma polycations opangidwa amapanga ma polyplexes okhala ndi DNA ndikuthandizira kupatsirana koyenera.Kugwiritsa ntchito mwayi wa BENSpm kulimbikitsa maselo a khansa ku ma apoptos opangidwa ndi TNFα, tikuwonetsa kuti DSS-BEN imathandizira kupha maselo amtundu wa TNFα.Zomwe zafotokozedwazo zimatsimikizira DSS-BEN ngati njira yoperekera ntchito ziwiri zomwe zimatha kupereka jini yochizira ndikuwongolera zotsatira za chithandizo cha majini chifukwa cha kuwonongeka kwa DSS-BEN kupita ku BENSpm komanso zotsatira zopindulitsa za BENSpm pa polyamine yosokoneza. metabolism mu khansa.
