5-Methylphenazinium methosulfate Cas: 299-11-6 99% Wobiriwira wobiriwira mpaka ufa wofiirira
| Nambala ya Catalog | XD90224 |
| Dzina lazogulitsa | 5-Methylphenazinium methosulfate |
| CAS | 299-11-6 |
| Molecular Formula | Chithunzi cha C14H14N2O4S |
| Kulemera kwa Maselo | 306.337 |
| Zambiri Zosungira | -15 mpaka -20 ° C |
| Harmonize Tariff Code | 29339980 |
Mafotokozedwe a Zamalonda
| Melting Point | 158-160 °C (dec.) (lit.) |
| Kuyesa | 99% |
| Fomu | Zolimba |
| Maonekedwe | ufa wobiriwira mpaka bulauni |
Mafuta a n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) ndi docosahexaenoic acid (DHA) asonyezedwa kuti apititse patsogolo mphamvu ya mankhwala a chemotherapeutic mu maphunziro a zachipatala kwa odwala khansa komanso kuchititsa kuti maselo a apoptotic afe mu vitro.Mpaka pano, EPA ndi DHA sizinafufuzidwepo mu multipleeloma (MM).Maselo a myeloma aumunthu (L363, OPM-1, OPM-2 ndi U266) ndi maselo ozungulira amagazi a mononuclear amtundu wa EPA ndi DHA, ndipo zotsatira za mitochondrial ntchito ndi apoptosis, caspase-3 activation, gene expression and drug toxicity adayesedwa.Kuwonekera kwa EPA ndi DHA kunachititsa kuti apoptosis ndichuluke ku bortezomib m'maselo a MM.Chofunika kwambiri, iwo sanakhudze viability wa yachibadwa munthu zotumphukira mononuclear maselo.Mafotokozedwe a Messenger RNA adawonetsa kuti EPA ndi DHA adasintha jini zomwe zimakhudzidwa ndi njira zingapo zolumikizirana kuphatikiza nyukiliya factor (NF) κB, Notch, Hedgehog, oxidative stress ndi Wnt.EPA ndi DHA zinaletsa ntchito ya NFκB ndikupangitsa apo ptosis kupyolera mu mitochondrial perturbation ndi caspase-3 activation.Kafukufuku wathu akuwonetsa kuti EPA ndi DHA zimathandizira kusankha kwa cytotoxic zotsatira mu MM ndikuwonjezera chidwi kwa bortezomib ndikuyitanitsa kuti tifufuzenso momwe mungagwiritsire ntchito mafutawa a n-3 polyunsaturated fatty acids pochiza MM.
