Zogulitsa

1. Cholinga cha phunziroli chinali kupanga chitsanzo chosavuta cha pharmacokinetic-pharmacodynamic (PK-PD) chomwe chingathe kuwonetsa kusintha kwa nthawi yonse ya kusintha kwa mapulateleti kuti athe kulosera za kuyambika ndi kuchuluka kwa thrombocytopenia, zomwe zimalepheretsa kwambiri kugwiritsa ntchito mankhwala osokoneza bongo. anticancer wothandizira 5-fluorouracil (5-FU), mu makoswe.2. Kuwerengera kwa mapulaneti kunayesedwa mu makoswe potsatira mtsempha wa intravenous wa mitundu yosiyanasiyana ya 5-FU kwa masiku a 4 kuti apeze deta yowunikira chitsanzo cha PK-PD.Chitsanzo chathu cha PK-PD chinali ndi PK-zipinda ziwiri, yokhala ndi zipinda zitatu zachitsanzo cha PD ndi magawo 10 a PK-PD.3. Pambuyo pa chithandizo cha 5-FU, chiwerengero cha mapulateleti chinachepa pang'onopang'ono kufika pa mlingo wa nadir, kusonyeza kubwereranso pamwamba pa mlingo woyambira musanabwerere ku miyeso yoyambira.Kuwerengera kwa mapulateleti a Nadir ndi ma rebounds osiyanasiyana ndi mulingo wa AUC0-∞.Mtundu womaliza wa PK-PD umadziwika bwino ndi kuchuluka kwa mapulateleti komanso magawo omaliza a PD adayesedwa motsimikiza kwambiri.4. Chitsanzo ichi cha PK-PD ndi kayeseleledwe kake kakhoza kuyimira chida chofunika kwambiri chowerengera ndi kulosera nthawi yonse ya kusintha kwa chiwerengero cha maselo a magazi, ndipo chikhoza kuthandizira pakupanga njira zochiritsira ndi 5-FU ndi kuwunika kwa ma anticancer agents osiyanasiyana. zomwe zimakhala zovuta kuzifufuza mwa anthu.