Zogulitsa

5-(Bromomethyl) -4- (4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl) amino]pyrimidine ndi mankhwala omwe amapeza zofunikira muzofukufuku zosiyanasiyana, mankhwala, ndi mafakitale.Pagululi limadziwika chifukwa cha kusinthasintha kwake komanso kuthekera komwe kuli nalo popanga mamolekyu apadera ndi mankhwala chifukwa cha kapangidwe kake komanso magulu othandizira. mankhwala.Kukhalapo kwa atomu ya bromine, atomu ya fluorine, gulu la isopropyl, ndi kapangidwe ka mphete ya pyrimidine kumapangitsa kukhala chomanga chokongola chopangira mamolekyu atsopano okhala ndi katundu wofunidwa.Akatswiri a zamankhwala ndi ofufuza zamankhwala amatha kusintha ndi kugwiritsira ntchito pawiriyi kuti adziwitse ntchito zenizeni kapena zochitika zomwe zimakhala zopindulitsa pazochitika za mankhwala osokoneza bongo kapena kupititsa patsogolo pharmacokinetic properties.Kuwonjezerapo, kukhalapo kwa magulu a methyl ndi methylsulfonyl mu pawiri kumapangitsa kuti ikhale yothandiza mu kaphatikizidwe ka organic.Gulu la methylsulfonyl limatha kuchita zinthu zosiyanasiyana, monga kusuntha kwa nucleophilic, kuchotsa, kapena oxidation, zomwe zimapangitsa kuti magulu osiyanasiyana azigwira ntchito alowe mu molekyulu yomwe mukufuna.Kusinthasintha kumeneku kumapangitsa kukhala kofunikira popanga ma organic compounds ovuta mu labotale. Kuphatikiza apo, kapangidwe ka kaphatikizidwe kameneka kamapangitsa kukhala kothandiza pa kafukufuku.Atomu ya fluorine ndi zina zolowa m'malo zimatha kupangitsa kuti pawiriyo pakhale mawonekedwe enieni a thupi kapena mankhwala, zomwe zimapangitsa kuti zikhale zomveka kufufuza zochitika zina kapena ngati gawo lofotokozera maphunziro oyerekeza.Ofufuza nthawi zambiri amagwiritsa ntchito mankhwalawa kuti amvetsetse kuyanjana kwachilengedwe, kuphunzira kamvekedwe kazinthu, kupanga njira zatsopano zopangira, kapena kupititsa patsogolo magwiridwe antchito amakampani omwe alipo kale.Ndikofunikira kuzindikira kuti kugwiritsa ntchito ndi momwe angagwiritsire ntchito 5-(Bromomethyl) -4-( 4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl) amino]pyrimidine ingasinthe malingana ndi malo enieni a kafukufuku kapena mafakitale.Zomwe zitha kugwiritsidwa ntchito pagululi zimapitilira zomwe tazitchula kale, ndipo phindu lake litha kufufuzidwa ndi akatswiri azamankhwala, akatswiri azamankhwala, akatswiri azachilengedwe, ndi asayansi ena omwe amatenga nawo gawo pakufufuza kwamankhwala, sayansi yazinthu, kapena kafukufuku wamamolekyu.Mwachidule, 5-(Bromomethyl) -4 -(4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl) amino]pyrimidine ndi gulu losunthika lomwe limakhala ndi lonjezo mu kafukufuku wamankhwala, mankhwala, ndi mafakitale.Mapangidwe ake enieni komanso magulu ochitapo kanthu amapangitsa kukhala chomangira chokongola chopangira mamolekyu atsopano amankhwala ndikufufuza momwe mankhwala amagwirira ntchito.Zomwe zitha kugwiritsidwa ntchito pagululi ndizokulirapo, ndipo kuwunikanso kwazinthu zake kungapangitse kupita patsogolo m'magawo angapo asayansi.