Makoswe anapatsidwa mlingo umodzi wa chomera chiyambi phenolic antioxidant Quercetin (QC) mu ufulu, liposome encapsulated ndi galactosylated liposome encapsulated mitundu 2 h isanafike hepatotoxic mlingo wa carbontetrachloride (CCl4, 40% v / v mu maolivi mafuta, 1 ml / kg b .wt).Mwa mitundu itatu yosiyanasiyana ya QC yoyesedwa, galactosylated liposomal QC yokha ndiyomwe idateteza kwambiri ku CCl4 yomwe idapangitsa kuwonongeka kwa hepatic oxidative.Pambuyo pa 24 h ya jakisoni (SC) maselo a chiwindi a makoswe adapezeka kuti amatha kuwonongeka kwa okosijeni ndi CCl4 ndipo adayang'aniridwa ndi kuchuluka kwa conjugated diene mu membrane ya chiwindi.Kuwonjezeka kawiri kwa conjugated diene ndi kulowetsedwa kwa CCl4 kunachepetsedwa mpaka mlingo wabwinobwino ndi galactosylated liposomal QC pre-mankhwala.Carbontetrachloride inachititsa kuwonongeka kwa nembanemba m'maselo a chiwindi ndipo idaweruzidwa ndi kuwunika kwa seramu yamagazi ndi chiwindi cha histopathological.Kuwonongeka kwa Membrane ndi kulowetsedwa kwa CCl4 kudawunikidwanso ndi kuchepa kwa plasma membrane (PM) yomangidwa ndi enzyme ya Na+/K+ ATPase ndipo idakulitsidwa kokha ndi chithandizo chamankhwala cha galactosylated liposomal QC.Carbontetrachloride inachititsa kuchepa kwakukulu kwa ma enzymatic ndi molecular endogenous antioxidant levels mu hepatic cells.The depression in antioxidant system in hepatic cell inalepheretsedwa ndi mlingo umodzi wa galactosylated lipsosomal QC isanayambe chithandizo cha CCl4.Kuchuluka kwa chiwindi kwa QC kunayesedwa pambuyo pa 2 h ya jekeseni wa flavonoid (8.9 micromol / kg kulemera kwa thupi) (mitundu yaulere kapena ya liposomal) ndipo 85% ya jekeseni ya QC inapezeka m'chiwindi pa nkhani ya galactosylated liposomal QC.Pamene 25% yokha ya mlingo wobayidwayo idadziwika mu chiwindi pomwe kuchuluka kwa QC yaulere kudayikidwa.Carbontetrachloride idapangitsanso kusintha kwa membrane fluidity ndipo idawunikidwa ndi kuchepa kwa membrane micro-viscosity.Kuchiza kwaufulu kwa QC sikunapangitse chitetezo ku CCl4 chomwe chinapangitsa kuwonjezeka kwa hepatic membrane fluidity, pamene galactosylated liposomal QC inateteza kwambiri kuwonjezeka.Zotsatira za kafukufukuyu zinawonetsa kuti QC mu galactosylated liposome ikhoza kukhala ndi chitetezo chachikulu ku CCl4 yomwe inachititsa kuvulala kwa hepatocellular.
