2'-Deoxyuridine Cas: 951-78-0
| Nambala ya Catalog | XD90583 |
| Dzina lazogulitsa | 2 - Deoxyuridine |
| CAS | 951-78-0 |
| Molecular Formula | C9H12N2O5 |
| Kulemera kwa Maselo | 228.20 |
| Zambiri Zosungira | 2 mpaka 8 ° C |
| Harmonize Tariff Code | 29349990 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Ufa woyera mpaka woyera |
| Kuyesa | 99% |
| Melting Point | 164-168 Deg C |
| Kutaya pa Kuyanika | <1.0% |
| Zotsalira pa Ignition | <0.1% |
Kugwiritsiridwa ntchito bwino kwa nayitrogeni mu ng'ombe ndikofunikira kuti ng'ombe zisawonongeke.Popeza ma purines ndi pyrimidines (PP) amapanga gawo lofunika kwambiri la rumen nitrogen, kumvetsetsa bwino mayamwidwe ndi kagayidwe kapakati ka PP ndikofunikira.Ntchito yomwe ilipo ikufotokoza za kakulidwe ndi kutsimikizika kwa njira yodziwika bwino komanso yeniyeni yodziwira panthawi imodzi ya purines 20 (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, thymine), uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), ndi zinthu zawo zowonongeka (uric acid, allantoin, β-alanine, β-ureidopropionic acid, β-aminoisobutyric acid) m'magazi a ng'ombe zamkaka.Njira yogwiritsira ntchito kwambiri yamadzimadzi ya chromatography yophatikizidwa ndi electrospray ionization tandem mass spectrometry (LC-MS/MS) idaphatikizidwa ndi milingo yofananira ndi matrix yofananira ndi zinthu zokhazikika zolembedwa ndi isotopically.Kusanthula kachulukidwe kake kunayambika ndi njira yatsopano yopangira chithandizo chamankhwala yomwe imakhala ndi mpweya wa ethanol, kusefera, kutulutsa madzi ndi kukonzanso.Magawo olekanitsa ndi kuzindikira panthawi ya kusanthula kwa LC-MS/MS adafufuzidwa.Zinatsimikiziridwa kuti kugwiritsa ntchito chitsanzo chowerengera chipika m'malo mokhala ndi mzere wofananira kumapangitsa kuti CV% ikhale yotsika komanso kusowa kwa mayeso oyenerera kunawonetsa kutsika kokhutiritsa kwa mzere.Njira chimakwirira ndende ranges kwa metabolite aliyense malinga ndi zitsanzo zenizeni, mwachitsanzo guanine: 0.10-5.0 μmol/L, ndi allantoin: 120-500 μmol/L.CV% pamagawo osankhidwa osankhidwa anali ochepera 25%.Njirayi ili ndi kubwereza kwabwino (CV%≤25%) ndi kulondola kwapakatikati (CV%≤25%) ndi kuchira kwabwino (91-107%).Ma metabolites onse adawonetsa kukhazikika kwanthawi yayitali komanso kukhazikika kwabwino mkati mwa kuthamanga (CV%≤10%).Madigiri osiyanasiyana amtheradi a matrix zotsatira adawonedwa mu plasma, mkodzo ndi mkaka.Kutsimikiza kwa zotsatira za matrix ofananirako kudawonetsa kuti njirayi inali yoyenera pafupifupi ma metabolites onse a PP omwe adayesedwa mu plasma yotengedwa kuchokera ku mtsempha wamagazi ndi portal hepatic, hepatic and gastrosplenic mitsempha komanso, kupatulapo ochepa, komanso mitundu ina monga nkhuku, nkhumba, mink, anthu ndi makoswe.
