Zogulitsa

1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxylic acid ethyl ester ndi mankhwala ovuta omwe asonyeza kuthekera m'madera osiyanasiyana a chemistry yamankhwala ndi kupeza mankhwala.Pano pali kufotokoza kwa ntchito zake m'mawu pafupifupi 300. Pagululi, lomwe nthawi zambiri limatchedwa ethyl ester derivative of 1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid, ndi ya gulu la pyrazolo [3,4-c] pyridine zotumphukira.Zotulutsa izi zakopa chidwi pakupeza mankhwala osokoneza bongo chifukwa cha kuthekera kwawo m'madera osiyanasiyana ochiritsira.Mmodzi yemwe angagwiritsire ntchito mankhwalawa ali m'munda wa kafukufuku wotsutsa khansa.Pyrazolo [3,4-c] zotumphukira za pyridine zawonetsa ntchito yolimbikitsa yolimbana ndi mitundu ingapo ya maselo a khansa.Kukhoza kwawo kuletsa njira zina zomwe zimakhudzidwa ndi kukula kwa chotupa ndi kupulumuka kumawapangitsa kukhala oyenerera kupanga mankhwala oletsa khansa.Maphunziro owonjezera amafunikira kuti afufuze momwe zimagwirira ntchito ndikuwunika momwe mankhwalawa amagwirira ntchito pazachipatala komanso zachipatala.Kuphatikiza apo, gululi lawonetsa lonjezo ngati wothandizira antibacterial.Yawonetsa zochita zolimbana ndi mabakiteriya osiyanasiyana, kuphatikiza mabakiteriya a gram-positive ndi gram-negative.Kutha kutsata mitundu ingapo kukuwonetsa kuthekera kwake polimbana ndi mabakiteriya osamva mankhwala, omwe akhala nkhawa yayikulu padziko lonse lapansi.Kafukufuku wowonjezereka akuyenera kufufuza momwe amachitira ndikuwunika momwe amachitira polimbana ndi matenda a bakiteriya.Kuonjezera apo, pyrazolo [3,4-c] zotumphukira za pyridine, kuphatikizapo chigawo ichi, zasonyeza kuti zingatheke pochiza matenda otupa ndi autoimmune.Kutupa kumagwira ntchito yofunika kwambiri pazinthu zosiyanasiyana monga nyamakazi ya nyamakazi ndi psoriasis.Zotulutsa izi zawonetsa zotsutsana ndi zotupa posintha njira zenizeni zomwe zimakhudzidwa ndi kuyankha kotupa.Izi zikuwonetsa kuthekera kwawo ngati othandizira othandizira kuthana ndi kutupa kosatha komanso matenda ogwirizana nawo.Kuwonjezera apo, gululi lawonetsa ntchito mu dongosolo lapakati lamanjenje (CNS).Adafufuzidwa chifukwa cha kuthekera kwake muzovuta zamanjenje monga matenda a Alzheimer's ndi Parkinson's.Pagululi amatha kusintha ma receptor ndi ma enzymes omwe amakhudzidwa ndikukula kwa matenda, zomwe zimatha kupereka zotsatira za neuroprotective.Komabe, kufufuza kwina kumafunika kuti mumvetsetse bwino momwe zimagwirira ntchito ndikuwunika momwe zimagwirira ntchito pochiza zovuta zovutazi.Mwachidule, 1- (4-Methoxyphenyl) -7-oxo-6- [4- (2-oxopiperidin-1-) yl)phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester imakhala ndi lonjezo m'madera angapo achire, kuphatikizapo odana ndi khansa, antibacterial, anti-inflammatory , ndi matenda a CNS.Kuthekera kwake kuli pakutha kutsata njira ndi ma receptor omwe amakhudzidwa ndi izi.Komabe, kufufuza kwina ndi kufufuza ndikofunikira kuti mufufuze mokwanira zomwe zingatheke, kukhathamiritsa katundu wake, ndikuwunika chitetezo chake ndi mphamvu zake pazachipatala.