Vancomycin hydrochloride Cas: 1404-93-9 Yoyera pafupifupi yoyera kapena yofiirira mpaka ufa wapinki
| Nambala ya Catalog | XD90197 |
| Dzina lazogulitsa | Vancomycin hydrochloride |
| CAS | 1404-93-9 |
| Molecular Formula | C66H76Cl3N9O24 |
| Kulemera kwa Maselo | 1485.7145 |
| Zambiri Zosungira | 2 mpaka 8 ° C |
| Harmonize Tariff Code | 29419000 |
Mafotokozedwe a Zamalonda
| Madzi | NMT 5.0% |
| Zitsulo zolemera | NMT 30ppm |
| pH | 2.5 - 4.5 |
| Bakiteriya endotoxins | NMT 0.33EU/mg wa Vancomycin |
| Kumveka kwa Yankho | Zomveka |
| Maonekedwe | Zoyera, pafupifupi zoyera, kapena zofiira mpaka pinki ufa |
| Vancomycin B | NLT 85% |
| Malire a monodechlorovancomycin | NMT 4.7% |
| Assay (microbial, anhydrous basis) | NLT 900ug/mg |
1. Kuchuluka kwa matenda a Staphylococcus aureus omwe amatengedwa ndi anthu ammudzi akuchulukirachulukira kwambiri.Chithandizo chogwira mtima chakhala chikukhudza kale kuchotsedwa koyambirira komanso kupereka maantibayotiki.Kafukufukuyu adapangidwa kuti adziwe momwe chithandizo chamankhwala chimagwirira ntchito pochiza matenda a m'manja.Kuyesa kosasinthika komwe kunachitika kunachitika pachipatala cha Level I County.Odwala pamanja analandira empiric intravenous vancomycin atalandira kapena mtsempha wa cefazolin.Zotsatira zinatsatiridwa pogwiritsa ntchito kuopsa kwa matenda, kuyankhidwa koyenera kwachipatala, ndi kutalika kwa kukhala.Mtengo wamtengo wapatali unawerengedwa pogwiritsa ntchito ndalama zonse kwa wodwala aliyense m'magulu onse awiri.Kusanthula kwachiwerengero kunachitika. Odwala makumi anayi ndi asanu ndi limodzi adalembedwa mu phunziroli.Makumi awiri ndi anayi anali randomized kuti cefazolin (52.2 peresenti) ndi 22 (47,8 peresenti) kuti vancomycin.Panalibe kusiyana kwa chiwerengero pakati pa mtengo wa mankhwala (p <0.20) kapena kutalika kwa nthawi yokhala (p <0.18) pakati pa magulu.Odwala randomized kuti cefazolin anali apamwamba zikutanthauza mtengo wa mankhwala poyerekeza ndi odwala randomized kuti vancomycin (p <0,05).Odwala omwe ali ndi matenda oopsa kwambiri anali ndi mtengo wokwera mtengo wamankhwala (p <0.0001) komanso kutalika kwa nthawi yayitali (p = 0.0002).Kumapeto kwa kafukufukuyu, chiwerengero cha anthu omwe amapeza methicillin-resistant S. aureus pachipatala cha olemba mabuku chinapezeka kuti ndi 72 peresenti, zomwe zinachititsa kuti kafukufukuyu athetsedwe msanga ndi bungwe loyang'anira mabungwe chifukwa cha zochitika zambiri. Kusatengera zina mwachisawawa.Kuchiza koyenera koyambirira kwa methicillin-resistant S. aureus sikunatsimikizidwe motsimikizika.Palibe kusiyana kwa zotsatira zogwiritsira ntchito cefazolin motsutsana ndi vancomycin monga wothandizira woyamba adadziwika.
2.Ndi kusintha kwa machiritso a zilonda pogwiritsa ntchito mankhwala ophera tizilombo toyambitsa matenda ndi kukonzanso kwaukadaulo, matenda a m'zigongono ayamba kuchepa koma amapezekabe m'maopaleshoni ena osankha.Cholinga cha kafukufukuyu chinali kuwunika chitetezo ndi mphamvu ya kugwiritsa ntchito vancomycin pamalo opangira opaleshoni kuti achepetse kuchuluka kwa matenda pambuyo potulutsa zigongono zolimba zomwe zidachitika pambuyo pa zoopsa. nthawi yachitika.Mu gulu lolamulira (odwala a 93), prophylaxis yosavuta yokhala ndi maantibayotiki a mtsempha wamagazi inkachitika;mu gulu la vancomycin (odwala 179), ufa wa vancomycin unagwiritsidwa ntchito mwachindunji pabalalo musanatseke pamodzi ndi mankhwala oletsa tizilombo toyambitsa matenda. nthawi: 2.40% -13.52%) poyerekeza ndi palibe (0%; nthawi yodalirika: 0-2%.04%) mu gulu la vacom ycin, lomwe linali losiyana kwambiri (P = .0027).Palibe zotsatira zoipa zomwe zinalembedwa kuchokera ku kugwiritsidwa ntchito kwachindunji kwa vancomycin powder.Kugwiritsira ntchito kwa vancomycin m'deralo kungakhale njira yodalirika yopewera matenda a pambuyo pa opaleshoni pambuyo pa kumasulidwa kwa chigongono kwa odwala omwe ali ndi vuto lachigono.
