Uridine-5'-diphosphoglucuronic asidi trisodium mchere CAS: 63700-19-6 ufa woyera
| Nambala ya Catalog | XD90382 |
| Dzina lazogulitsa | Uridine-5'-diphosphoglucuronic asidi trisodium mchere |
| CAS | 63700-19-6 |
| Molecular Formula | C15H19N2O18P2Na3 |
| Kulemera kwa Maselo | 646.20 |
| Zambiri Zosungira | -4 ° C |
Mafotokozedwe a Zamalonda
| Kuyesa | 99% |
| Maonekedwe | White ufa |
Kafukufuku wapanoyu akufuna kufufuza momwe kawopsedwe ka irinotecan ndi biotransformation ya glucoaurantio-obtusin kupita ku aurantio-obtusin.Kuwongolera kwa intraperitoneal (ip) kwa 100 mg/kg aurantio-obtusin kumawonjezera kawopsedwe wa irinotecan, koma kugwiritsa ntchito ip 100 mg/kg glucoaurantio-obtusin kunawonetsa chikoka chocheperako pa kawopsedwe ka irinotecan.Kuphatikiza apo, makinawo adafotokozedwa pozindikira kuthekera koletsa kwa glucoaurantio-obtusin ndi aurantio-obtusin ku glucuronidation metabolism ya SN-38 yomwe imawonedwa kuti ndiye chinthu chachikulu chomwe chimayambitsa kawopsedwe wa irinotecan.Zotsatira zake zidawonetsa kuti aurantio-obtusin adawonetsa kuletsa kwamphamvu kwa glucuronidation ya SN-38, koma kuletsa kopanda mphamvu kwa glucoaurantio-obtusin ku SN-38 glucuronidation kudawonedwa.Zotsatira izi zidawonetsa kuti biotransformation ya glucoaurantio-obtusin kupita ku aurantio-obtusin idakulitsa kawopsedwe wa irinotecan kudzera pakuletsa kwa SN-38 glucuronidation.
