Zogulitsa

masensa PH anapangidwa ndi anodically electrodepositing iridium oxide mafilimu (AEIROFs) pa ma microelectrodes pa tchipisi ndi yokutidwa ndi poly(ethyleneimine) (PEI) kuti makina bata.Izi zikuwonetsa kuyankha kwapamwamba kwa Nernstian ku pH kuchokera ku pH 4.0 mpaka 7.7 mu buffer wopanda phosphate wa chloride.Pamwamba pa chipcho chidakutidwa ndi fibronectin polumikizira ma cell a porcine aortic endothelial cell (PAECs).Mphamvu yogwira ntchito ya sensa ya pH yowunikira kusintha kwa pH yakumaloko idafufuzidwa polimbikitsa ma PAEC ndi thrombin.Zotsatira zathu zikuwonetsa kuti thrombin idapangitsa kuti ma PAEC achuluke kwambiri komanso kusungunuka kwa fibronectin, zomwe zimapangitsa kuti pH yakumaloko ikhale yochepa.Kugwiritsiridwa ntchito kwa PD98059, mitogen-activated protein kinase (MAPK) inhibitor, kuchepetsa extracellular acidification ndi kuwonjezeka kwa pH yakomweko kunawonedwa.Kafukufukuyu akuwonetsa kuti masensa athu a pH amatha kuthandizira kufufuza kwa mayankho amtundu wamtundu wokondoweza poyang'anira nthawi yeniyeni, kusintha kwa pH kwa maselo omwe amamangiriridwa ku masensa.