Zogulitsa

Pawiri tert-Butyl 6- [(1E)-2- [4-(4-fluorophenyl)-6-(1-methylethyl)-2--[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2, 2-dimethyl-1,3-dioxane-4-acetate ndi mankhwala ovuta omwe amatha kugwiritsidwa ntchito m'madera osiyanasiyana kuphatikizapo mankhwala, agrochemicals, ndi chemistry. pyrimidine, ndi mphete ya dioxane.Kukhalapo kwa magulu a tert-butyl ndi acetate kumasonyeza kukhazikika ndi kumasuka kwa kugwiritsira ntchito.M'munda wa mankhwala, chigawo ichi chikhoza kukhala ndi mphamvu yogwiritsira ntchito mankhwala (API) kuti apange mankhwala atsopano.Kukhalapo kwa gulu la pyrimidine kumasonyeza kuti zotheka kuyanjana ndi zolinga zamoyo, zomwe zimapangitsa kuti zikhale zofunikira kwambiri pakupeza mankhwala.Gulu la ethenyl lomwe likupezeka m'gululi limayambitsa mitundu yambiri yamitundu yosiyanasiyana, yomwe ingakhale yopindulitsa pakuwongolera mphamvu ya pawiri, mphamvu yake, ndi pharmacokinetic katundu.Zomwe zili m'gulu la ethenyl, monga magulu a methyl ndi methylsulfonyl amino, zimapititsa patsogolo kusiyanasiyana kwa mankhwala a pawiri ndipo zingathandize kuti bioactivity yake kapena mankhwala monga mankhwala. , kuphatikizapo monga solubility enhancer kapena njira yobweretsera zinthu zina zogwira ntchito.Kukhalapo kwake mu mankhwalawa kumasonyeza kuti kungapangitse kusungunuka kwapawiri kapena kukhazikika.Kupatulapo mankhwala opangira mankhwala, mankhwalawa angapezenso ntchito mu agrochemicals ngati wothandizira mbewu.Itha kuwonetsa zochitika zowononga tizilombo kapena kukhala ndi zopindulitsa zina pakukula kwa mbewu ndi thanzi. Kuphatikiza apo, mawonekedwe a pawiri, monga gulu la tert-butyl ndi mphete ya dioxane, imapangitsa kuti ikhale yowoneka bwino pakugwiritsa ntchito chemistry.Itha kukhala ngati chomangira kapena kalambulabwalo wa kaphatikizidwe kazinthu zatsopano zokhala ndi zinthu zapadera, monga zida za polymeric kapena mankhwala apadera.Mwachidule, tert-Butyl 6-[(1E) -2-[4-(4-fluorophenyl) -6-(1-methylethyl) -2--[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate ndi gulu lomwe lingagwiritsidwe ntchito pamankhwala, agrochemicals, ndi zinthu chemistry.Kapangidwe kake kapadera ka mankhwala ndi magulu ogwirira ntchito akuwonetsa kukwanira pakupanga mankhwala, kuteteza mbewu, kapena kaphatikizidwe kazinthu zatsopano.Komabe, kafukufuku wowonjezera akufunika kuti afufuze mokwanira za bioactivity yake, kusankhidwa kwa chandamale, katundu wa pharmacokinetic, ndi chitetezo asanayambe kugwiritsidwa ntchito pazinthu zina.