Zogulitsa

Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) pyridin-3-yl) piperazine-1-carboxylate ndi pawiri yomwe ili ndi kuthekera kwakukulu mu chemistry yamankhwala ndi chitukuko cha mankhwala.Kapangidwe kake ka maselo kakang'ono kamene kamasonyeza ntchito zosiyanasiyana zomwe zingagwiritsidwe ntchito.Chigawo ichi chili ndi piperazine-1-carboxylate core, yomwe imagwiritsidwa ntchito kwambiri mu chemistry yamankhwala chifukwa cha kusinthasintha kwake komanso njira zambiri zopangira mankhwala.Kukhalapo kwa piperazine moiety kumapangitsa kuti pakhale kuyanjana ndi zolandilira zosiyanasiyana ndi michere, ndikupangitsa kukhala wokonda chidwi pakukula kwa othandizira achire. 8-dihydropyrido [2,3-d] pyrimidin-2-yl gulu mu dongosolo limapereka ntchito yotheka ya mankhwala.Zotulutsa za pyrido [2,3-d] pyrimidine zotere zaphunziridwa mozama chifukwa cha anti-yotupa, antiviral, ndi anticancer properties.Magulu a cyclopentyl ndi methyl amathandiza kuti lipophilicity ya pawiri ikhale yowonjezereka, yomwe ingapangitse kuti ma cell permeability ndi bioavailability.Kusinthasintha kumeneku kumakhala kofunikira mu mankhwala a mankhwala, chifukwa kumapangitsa kuti pakhale mankhwala amphamvu kwambiri komanso osankhidwa.Gulu la pyridin-3-yl mu kapangidwe kameneka limakhala ngati ligand lomwe lingakhalepo kwa ma receptor osiyanasiyana, monga G protein-coupled receptors (GPCRs).Izi zikusonyeza kuti chigawocho chikhoza kukhala ndi zotsatira pa njira zowonetsera ma intracellular ndipo zikhoza kufufuzidwa mowonjezereka chifukwa cha kuthekera kwake monga modulator kapena wotsutsana ndi ma receptor apadera omwe amakhudzidwa ndi matenda. (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate mfundo zazikulu kuthekera kwake pakupanga mankhwala atsopano.Zimapereka mwayi wofufuza kuletsa kwa ma enzyme, kumangiriza kwa ma receptor, komanso kusinthasintha kwazinthu zosiyanasiyana zamoyo.Ndi kufufuza kwina ndi kukhathamiritsa, chigawochi chikhoza kukhala chothandizira pakupanga mankhwala okhudzana ndi khansa, kutupa, kapena matenda ena.Mapangidwe ake apadera komanso zochitika zamoyo zomwe zimatha kupangitsa kuti likhale losangalatsa pakufufuza ndi chitukuko chamankhwala. Pomaliza, tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl- 5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate imakhala ndi lonjezo ngati chigawo chosunthika cha chitukuko cha mankhwala.Kapangidwe kake kovutirapo komanso zochitika zachipatala zomwe zitha kupangitsa kuti ikhale yochititsa chidwi kuti ifufuzidwenso ngati chithandizo chothandizira matenda osiyanasiyana.