Zogulitsa

Telithromycin idakhazikitsidwa koyamba ku Germany ngati chithandizo chapakamwa kamodzi patsiku kwa matenda opumira kuphatikiza chibayo chopezeka ndi anthu ammudzi, kuchulukitsa kwa bakiteriya kwa matenda a bronchitis, sinusitis pachimake ndi zilonda zam'mimba/pharyngitis.Izi zochokera ku semisynthetic za macrolide erythromycin zachilengedwe ndi ketolide yoyamba kugulitsidwa, gulu latsopano la maantibayotiki okhala ndi C3-ketone m'malo mwa gulu la L-cladinose.14-membala wa mphete antibacterial wothandizira amalepheretsa kaphatikizidwe ka mapuloteni a bakiteriya pomanga magawo awiri a 50S subunit ya bakiteriya ribosomes.Imawonetsa zochitika zamphamvu mu vitro motsutsana ndi tizilombo toyambitsa matenda wamba monga Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis ndi Streptococcus pyogenes komanso tizilombo toyambitsa matenda.Gulu la 3-keto limapereka kukhazikika kwa acidic ndikuchepetsa kutsika kwa macrolide-lincosamide-streptogramin B kukana komwe kumawonedwa pafupipafupi ndi macrolides.Zotsalira za C11-C12 carbamate zotsalira sizikuwoneka kuti zikungowonjezera kuyanjana kwa malo omangira ribosomal komanso kuti zikhazikitse pawiri motsutsana ndi esterase hydrolysis ndikupewa kukana chifukwa cha kuchotsedwa kwa macrolides mu selo ndi mpope wa efflux wophatikizidwa ndi jini ya mef m'matenda ena. .Telithromycin ndi inhibitor yopikisana komanso gawo lapansi la CYP3A4.Komabe, mosiyana ndi ma macrolides angapo monga troleandomycin, sapanga khola loletsa CYP P-450 Fe2 + -nitrosoalkane metabolite complex yomwe ingakhale hepatotoxic.Mankhwala bwino analekerera ndi bwino anagawira m`mapapo mwanga zimakhala, bronchial secretions, tonsils ndi malovu.Zimakhala zokhazikika kwambiri mu ma azurophil granules a polymorphonuclear neutrophils potero amathandizira kutumiza kwake ku mabakiteriya a phagocytosed.