Zogulitsa

Matenda a shuga mellitus amagwirizana ndi kutupa kosalekeza kosalekeza komanso kupsinjika kwa okosijeni.Bupleurum Polysaccharides (BPs), yotalikirana ndi Bupleurum smithii var.parvifolium ili ndi anti-yotupa komanso anti-oxidative properties.Komabe, ndi zochepa zomwe zimadziwika ponena za chithandizo chake pa matenda a shuga.Pakuyesaku, zotsatira za BPs pakuchepetsa matenda a shuga komanso njira zoyambira zidafufuzidwa.Mtundu wa mbewa za shuga unakhazikitsidwa kudzera mu jakisoni wotsatizana wa intraperitoneal wa streptozotocin (100 mg/kg kulemera kwa thupi) kwa masiku awiri.Mbewa zokhala ndi shuga m'magazi apamwamba kuposa 16.8mmol/L zidasankhidwa kuti ziyesedwe.Makoswe a shuga amaperekedwa pakamwa ndi BP (30 ndi 60 mg / kg) kamodzi patsiku kwa masiku 35.Ma BP sanangochepetsa kwambiri kuchuluka kwa shuga m'magazi, komanso adachulukitsa a seramu insulin ndi glycogen ya chiwindi mu mbewa za matenda ashuga poyerekeza ndi mbewa zachitsanzo.Kuphatikiza apo, kuyang'anira kwa BP kunapangitsa kuti insulini iwoneke ndikupondereza apoptosis mu kapamba wa mbewa za matenda ashuga.Kuwona kwa histopathological kunawonetsanso kuti BPs imateteza kapamba ndi chiwindi kuti zisawonongeke ndi okosijeni ndi kutupa.Zotsatirazi zikusonyeza kuti BPs imateteza maselo a pancreatic β ndi hepatocytes ya chiwindi ndi kuchepetsa matenda a shuga, omwe amagwirizana ndi anti-oxidative ndi anti-inflammatory properties.