Zogulitsa

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone, wotchedwanso CF3-112, ndi mankhwala pawiri ndi ntchito zingapo zofunika m'munda wa chemistry mankhwala ndi mankhwala. chitukuko.Mmodzi mwa ntchito zazikulu za CF3-112 ndi monga kinase inhibitor.Kinase ndi michere yomwe imayang'anira njira zosiyanasiyana zama cell m'thupi, kuphatikiza kukula kwa maselo, magawano, ndi kulumikizana.Kuwonongeka kwa kinases nthawi zambiri kumalumikizidwa ndi matenda monga khansa ndi matenda a autoimmune.CF3-112 yapezeka kuti ikuwonetsa zoletsa zolimbana ndi ma kinase ena, zomwe zimapangitsa kuti ikhale yodalirika pakupanga njira zochiritsira zomwe akuzifuna. Makamaka, CF3-112 yawonetsa ntchito yoletsa motsutsana ndi Aurora kinases, yomwe imagwira ntchito yofunika kwambiri pakugawikana kwa ma cell ndi ma cell. nthawi zambiri amawonetsedwa kwambiri m'maselo a khansa.Mwa kusankha kulunjika ndi kuletsa kinasewa, CF3-112 ingathandize kuletsa kuchulukana kwachangu kwa maselo a khansa ndikupereka chithandizo chamankhwala. Komanso, CF3-112 yawonetsa zochita motsutsana ndi kinase ena monga FLT3 ndi JAK2, zomwe zimakhudzidwa ndi hematological. matenda monga acute myeloid leukemia (AML) ndi myeloproliferative neoplasms.Kuletsa kinases awa ndi CF3-112 ali ndi kuthekera kusokoneza ma signways omwe amayendetsa kukula ndi kupulumuka kwa maselo a khansa, kupereka mwayi watsopano wochizira matenda awa. Kuphatikiza pa ntchito yake yoletsa kinase, CF3-112 ikhoza kukhala ndi anti -zotupa zotsatira.Kutupa ndi kuyankha kovuta kwachilengedwe komwe kumayambitsa matenda ambiri, kuphatikiza matenda a autoimmune komanso kutupa kosatha.CF3-112 yasonyeza lonjezo ngati cholepheretsa njira zina zotupa, zomwe zingathe kupereka njira yochiritsira yosamalira mikhalidwe imeneyi.Ngakhale kuti CF3-112 ili ndi kuthekera kwakukulu, ndizofunika kudziwa kuti kufufuza kwina ndi chitukuko n'kofunika kuti timvetse bwino mphamvu yake, chitetezo. mbiri, ndi ntchito mulingo woyenera.Mofanana ndi pawiri iliyonse, kuyezetsa mozama ndi kufufuza koyambirira kumafunika kuti apite patsogolo ku mayesero a zachipatala a anthu.Ntchito yake ya kinase inhibitory, makamaka motsutsana ndi Aurora kinases, FLT3, ndi JAK2, imayiyika ngati yomwe ingatheke pakupanga njira zochizira khansa komanso matenda a hematological.Ma anti-inflammatory properties amasonyezanso ntchito zomwe zingagwiritsidwe ntchito poyang'anira matenda a autoimmune ndi kutupa kwanthawi yaitali.Komabe, kufufuza kwina n'kofunika kuti mutsegule mphamvu zake zonse zochiritsira ndikuwunika chitetezo chake ndi mphamvu zake.