Zogulitsa

The ExPortal protein secretion organelle mu Streptococcus pyogenes ndi anionic phospholipid-containing membrane microdomain yolemeretsedwa mu Sec translocons ndi postsecretion protein biogenesis factor.Polymyxin B imamangiriza ndikusokoneza kukhulupirika kwa ExPortal, zomwe zimapangitsa kuti pakhale kuperewera kwa poizoni wambiri.Kuti tizindikire zinthu zomwe zimakhudza bungwe la ExPortal, chithunzithunzi cha majini chinachitidwa kuti chisankhidwe zosinthika zodziwikiratu za polymyxin B zolimbana ndi kukhulupirika kwa ExPortal.Kuphatikizikanso kwa ma genome 25 osagwirizana ndi masinthidwe osinthika kuchokera kumodzi mpaka anayi pamtundu uliwonse wosakanikirana wophatikizidwa makamaka mkati mwamagulu 10 amtundu.Kupanga zosinthika zokhala ndi zochotsa kapena zoyikapo zikuwonetsa kuti majini 7 apakati amapereka kukana komanso kupititsa patsogolo kukhulupirika kwa ExPortal chifukwa chakulephera kugwira ntchito, pomwe 3 mwina anali chifukwa chogwira ntchito komanso/kapena kuphatikiza.Mitundu yotsutsa kwambiri imaphatikizapo zolembera za lipid biosynthesis, majini angapo omwe amakhudzidwa ndi kupeza zakudya, ndi mitundu yosiyanasiyana ya majini yomwe imakhudzidwa ndi kupsinjika maganizo.Mamembala awiri amgulu lomaliza amagwiranso ntchito ngati owongolera atsopano a SpeB cysteine ​​protease.Kuwunika kwa masinthidwe omwe nthawi zambiri amakhala akutali, kuchotsedwa kwa nucleotide imodzi pamndandanda wa zotsalira za 9 zotsatizana za adenine mu pstS, kuyika gawo la chotengera chapamwamba cha Pi transporter, kukuwonetsa kuti kutsatizanaku kumagwira ntchito ngati masinthidwe a molekyulu kuti athe kuwongolera kupsinjika.Pamodzi, izi zikuwonetsa kukhalapo kwa kuyankha kwa kupsinjika kwa membrane komwe kumalimbikitsa kukhulupirika kwa ExPortal komanso kukana cationic antimicrobial peptides.