Zogulitsa

Kuti mufufuze zida zatsopano za anticancer zochokera ku platinamu zomwe ndizosiyana ndi kapangidwe kake ndi kachitidwe ka cisplatin mwachikhalidwe popanga bifunctional intrastrand 1,2 GpG adduct, ma platinamu + DNA adducts omwe ali ndi machitidwe osagwirizana kwambiri adaphunziridwa.Zinanenedwa kuti othandizira a testosterone-based platinamu (II) omwe ali ndi ntchito yayikulu yolimbana ndi khansa.Kuphatikiza apo, zidapezekanso kuti ma testosterone-based platinamu othandizira angapangitse kuti DNA helix iwonongeke kwambiri ndikupindika pamagulu omwe si a testosterone-based platinamu.Komabe, njira zolumikizirana za ma platinum agents omwe ali ndi DNA pamlingo wa atomiki sizinadziwikebe mpaka pano.Mu ntchito yapano, tidagwiritsa ntchito zofananira zamamolekyulu (MD) ndi kuwerengera kwa DNA conformational dynamics kuti tiphunzire kupotoza kwa DNA kwa testosterone - based platinamu + DNA, platinamu yopangidwa bwino ndi testosterone + DNA komanso platinamu + DNA yosagwirizana ndi testosterone.Zotsatira zikuwonetsa kuti kuyanjana kosinthika kwa testosterone-based platinamu wothandizira wokhala ndi molekyulu ya DNA kungayambitse kusokoneza kwakukulu kwa DNA kuposa kuyanjana kwa nkhope ya testosterone-based platinamu wothandizira wokhala ndi molekyulu ya DNA.Kufufuza kwina kwa platinamu yosagwirizana ndi testosterone kumawonetsa kupezeka kwa kusintha kocheperako kwa DNA conformation chifukwa chosowa testosterone ligand mwa wothandizira wotere.Kutengera kusanthula kwa DNA dynamics, mayendedwe a DNA okhudzana ndi kusintha kwa magawo a DNA groove ndi kuwonongeka kwa ma hydrogen bond of DNA base pairs adakambidwanso mu ntchitoyi. testosterone-based platinamu + DNA adduct, yomwe ndi yosiyana ndi kuyanjana kwa nkhope komwe kumayambitsidwa ndi cholumikizira cholimba mu testosterone-based platinamu agent.Kufufuza kwapano kumapereka chidziwitso chofunikira cha DNA conformation yomwe imakhudzidwa ndi testosterone-based platinamu complex pa atomiki.