Penicillin G mchere wa potaziyamu CAS: 113-98-4 99% ufa woyera
| Nambala ya Catalog | XD90351 |
| Dzina lazogulitsa | Penicillin G mchere wa potaziyamu |
| CAS | 113-98-4 |
| Molecular Formula | Chithunzi cha C16H17KN2O4S |
| Kulemera kwa Maselo | 372.48 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29411000 |
Mafotokozedwe a Zamalonda
| Kutaya pa Kuyanika | <1.0% |
| Mtundu wa Solution | Zosawoneka bwino kwambiri kuposa mphamvu ya Y2 kapena YG2 yamitundu yosiyanasiyana |
| pH | 5-7.5 |
| Zogwirizana nazo | <1.0% |
| Kuyesa | 99% |
| Mphamvu | 1440 - 1680u/mg |
| Maonekedwe | White mpaka pafupifupi woyera crystalline ufa |
| Kumveka kwa Yankho | Osapitilira opalescent kuposa kuyimitsidwa kwachinsinsi 1 |
| Kutumiza | NLT 90% |
| Butyl acetate | NMT 0.05% |
| Butanol | NMT 0.12% |
e anafotokoza kale kuti molekyulu ya autoinducer, yodziwika kuti 1,3-diaminopropane (1,3-DAP), imatulutsidwa ndi Penicillium chrysogenum ndi Acremonium chrysogenum.Pogwiritsa ntchito zikhalidwe za fermentor zoyendetsedwa ndi pH zomwe tawona m'nkhaniyi kuti 1,3-DAP ndi spermidine zimalimbikitsa momveka bwino biosynthesis ya benzylpenicillin mu P. chrysogenum, muzofotokozera komanso zovuta kupanga penicillin.Zonse 1,3-DAP ndi spermidine, koma osati putrescine (1,4-diaminobutane), zimapanga kuwonjezeka kwakukulu kwa zolemba za penicillin biosynthetic gene pcbAB, pcbC ndi penDE.Ma polyamines awa samakhudza mafotokozedwe a jini ya pH-stress regulator pacC jini, motero samapatula kuti zotsatira za 1,3-DAP ndi spermidine zimachitika chifukwa cha kusintha kwa pH control mechanism.Kufotokozera kwa mitundu itatu ya penicillin biosynthetic gene kumachepetsedwa kwambiri mu laeA-knock-down mutant ya P. chrysogenum, yomwe imatulutsa benzylpenicillin wochepa kwambiri.Chosangalatsa ndichakuti, 1,3-DAP ndi spermidine zimabwezeretsa kusintha kwa laeA, ndikubwezeretsanso kupanga kwa penicillin.Kuphatikiza apo, 1,3-DAP ndi spermidine zidakulitsa kufotokozera kwa laeA mu vuto la makolo ndikubwezeretsanso milingo ya zolemba za laeA mu laeA knock-down mutant.Kutengera pamodzi zotsatirazi zikuwonetsa kuti mphamvu yolimbikitsira ya mamolekyu a inducer 1,3-DAP ndi spermidine imagwira ntchito, makamaka mwa gawo, kudzera pakukondoweza kwa mawu a laeA, wolamulira wapadziko lonse lapansi yemwe amachita epigenetically pofotokoza zamtundu wachiwiri wa metabolite. ndi heterochromatin reorganization.
