Zogulitsa

Mankhwala atsopano ochepetsa thupi komanso ochepetsa lipid: Orlistat ndi mtundu watsopano wamankhwala ochepetsa thupi komanso ochepetsa lipid omwe amadziwika padziko lonse lapansi.Ndi malonda apachaka a US $ 538 miliyoni, orlistat pakali pano ali ndi 80% ya msika wolemera padziko lonse lapansi, ndipo malonda apachaka ku Hong Kong, China okha amafika US $ 80 miliyoni.Pakali pano ndi mankhwala okhawo ochepetsa thupi a OTC padziko lapansi.Anthu opitilira 40,000,000 padziko lonse lapansi adatenga ndikuchepetsa thupi.Pakali pano ndi malonda ogulitsa kwambiri kuwonda.Ndi othandiza kuwonda.Orlistat ndi yamphamvu komanso yogwira ntchito kwa nthawi yayitali m'mimba ya lipase inhibitor.Mwa kutsekereza mwachindunji kuyamwa kwamafuta m'thupi muzakudya, kudya kwa zopatsa mphamvu ndi mafuta kukakhala kocheperako, mafuta amthupi amachepetsedwa mwachilengedwe, kuti akwaniritse cholinga chaonda.Ndizotetezeka kuonda, zosakaniza zogwira ntchito sizimalowa m'magazi, ndipo sizigwira ntchito pakatikati pa mitsempha.

Orlistat ndi m'mimba ya lipase inhibitor yomwe imagwira ntchito nthawi yayitali komanso yamphamvu, yoyera kapena yoyera yoyera kutentha kutentha, osasungunuka m'madzi, kusungunuka mu chloroform, komanso kusungunuka mosavuta mu ethanol.Malo omwe akugwira ntchito pa serine ya chapamimba lipase ndi pancreatic lipase amapanga ma covalent bond kuti aletse ma enzymes.Mafuta omwe ali m'zakudya sangathe kuwola kukhala mafuta acids aulere ndi monoacylglycerol, kotero kuti mafuta sangathe kuyamwa ndi kugwiritsidwa ntchito, potero amachepetsa kudya kwa calorie m'thupi ndikuwongolera kulemera kwa thupi.Mankhwalawa safuna mayamwidwe mwadongosolo kuti agwire ntchito.Mlingo wanthawi zonse, kuyamwa kwamafuta kumatha kuletsedwa ndi 30%.Simatengeka kawirikawiri pambuyo pa makonzedwe amkamwa, ndipo amatha kutsekedwa ndi metabolism m'matumbo.Malo a metabolic ali pakhoma la m'mimba, ndipo theka la moyo wake ndi pafupifupi maola 14 mpaka 19.Pafupifupi 97% ya mankhwalawa amachotsedwa ndi ndowe, zomwe 83% zimachotsedwa mu mawonekedwe ake oyambirira.

Itha kugwiritsidwa ntchito kuchipatala mu kunenepa kwambiri komanso hyperlipidemia.Nthawi zambiri, mlingo wa 120 mg ukhoza kutengedwa pakamwa, katatu patsiku, ndi chakudya kapena ola limodzi mutatha kudya.Kunenepa kumatha kutsika pakatha milungu iwiri mutamwa mankhwalawa.Itha kutengedwa mosalekeza kwa miyezi 6 mpaka 12.Ngati mlingo wawonjezeka kupitirira 400 mg patsiku, zotsatira zake sizidzakulitsidwanso.