Zogulitsa

Nicotinamide Riboside ingagwiritsidwe ntchito pofufuza zamoyo za gene circadian reprogramming transcriptome mu chiwindi chozindikiritsa njira za ukalamba mu mbewa.Zimawonjezeranso NAD+ mu cerebral cortex ndikuchepetsa kuwonongeka kwachidziwitso mu mtundu wa mbewa wa transgenic wa matenda a Alzheimer's.

Nicotinamide adenine dinucleotide (NAD +) ndi coenzyme yofunikira kwambiri yomwe, ikachepetsedwa kukhala NADH, imakhala ngati chochepetsera kupereka ma electron kuti oxidative phosphorylation ndi kaphatikizidwe ka ATP mu mitochondria.NAD+ ndi cofactor yofunikira ya michere monga sirtuins, ADP-ribosyltransferases (ARTs), ndi Poly [ADP-ribose] polymerases (PARPs) ndipo imadyedwa mosalekeza ndi ma enzymes awa.Chiŵerengero cha NAD +/NADH ndi gawo lofunika kwambiri la redox ya selo.(Verdin 2015).Mwa zina, NAD kapena NADP yofananira imatenga nawo gawo mu kotala la machitidwe onse am'manja (Opitz Heiland 2015).Pali zigawo zosiyana za NAD + mu nucleus, mitochondria, ndi cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) itha kusinthidwa kukhala NAD+ kudzera pa sitepe yapakatikati yomwe imasinthidwa kukhala nicotinamide mononucleotide (NMN) ndi NR kinase (Nrk) kenako kukhala NAD+ ndi NMNATs.NR imapezeka mwachilengedwe muzakudya zina koma pazakudya zotsika kwambiri (monga kuchuluka kwa micromolar).M'mbiri, NR inali yovuta kupeza ndalama zambiri zoyeretsedwa, koma chifukwa cha kupita patsogolo kwa njira zophatikizira (Yang 2007), kuyambira Juni 2013, imagulitsidwa ngati chowonjezera chazakudya.