nkhani

Neocuproine reagent ndi reagent yotsimikizira mkuwa, kristalo yoyera kapena yachikasu-bulauni, yokwiyitsa.Amagwiritsidwa ntchito ngati reagent kwa mtima wa cuprous, photometric mtima wamkuwa, kutsimikiza kwa kopitilira muyeso-yaying'ono shuga shuga;organic synthesis.Neocuproine hydrochloride monohydrate yagwiritsidwa ntchito poyeza kusungunuka kwa mkuwa mu Cu-Ni alloys pogwiritsa ntchito njira ya colorimetric.Zagwiritsidwanso ntchito pokonzekera yankho la ma complexing agent powerenga ma antioxidant capacity assays mu zitsanzo za biology kutengera Cu kuchepetsa ma complexes.Itha kugwiritsidwa ntchito ngati kalambulabwalo yokonza neocuproine, yomwe imagwiritsidwa ntchito ngati chowunikira chowunikira kudziwa zamkuwa mu zitsanzo zachilengedwe pogwiritsa ntchito njira ya spectrophotometric.

Posachedwapa, Eribulin yavomerezedwa kuti igulitsidwe ndi National Medical Products Administration (NMPA) ya dziko langa pofuna kuchiza odwala khansa ya m'mawere yobwerezabwereza kapena ya metastatic omwe alandira mankhwala osachepera awiri. mankhwala (kuphatikizapo anthracyclines ndi taxans) m'mbuyomu.Zabweretsa njira yatsopano yochizira matenda a khansa ya m'mawere ku China, Imabweretsanso njira zambiri zothandizira odwala.
Eribulin ndi non-taxane tubulin inhibitor.Mosiyana ndi taxane ndi vinblastine tubulin inhibitors, Eribulin ali ndi njira yapadera yochitira zinthu, zomwe zimapangitsa Eribulin Ikadali yothandiza kwa odwala pambuyo pokana mankhwala ku yew;Eribulin imakhalanso ndi zotsatira zosagwirizana ndi cytotoxic, kuphatikizapo kukonzanso mitsempha, kuonjezera kutsekemera kwa mankhwala ena mu chotupa microenvironment, synergizing mankhwala ena, ndi kubwezeretsa maselo a chotupa The epidermal-mesenchymal transition ndi zina zotero.

Kuchokera pakuphatikizana kwa halichondrin B, kugwiritsa ntchito ma reagents atsopano amkuwa monga zapakati, kusinthidwa kwa Eribulin, kupanga mafakitale a Eribulin, asayansi ochokera kumakampani amaphunziro ndi zamankhwala akhala akufufuza zaka zopitilira 20.Zinthu zachilengedwe zochokera kunyanja zasanduka mankhwala omwe amatha kuchiza khansa.Kafukufuku ndi chitukuko cha Eribulin ndi chifukwa chakuti reagent yamkuwa yatsopano ndiyofunikira kwambiri ngati API yake yapakatikati.Chombo chatsopano chamkuwa chimakhala ndi ntchito yaikulu monga mankhwala apakatikati ndi reagent yoyeretsa zida zapamwamba.

Mapangidwe a mamolekyu a Eribulin ali ndi malo 19 a chiral, ndipo masitepe a kaphatikizidwe ndiatali ngati masitepe 62.Mpaka pano, Eribulin amawonedwabe ndi mafakitale ngati mankhwala ovuta kwambiri osagwiritsa ntchito peptide opangidwa ndi kaphatikizidwe koyera, ndipo amatha kutchedwa Mount Everest mumakampani opanga mankhwala.
Mndandanda wopambana wa Eribulin ukuwonetsa kukwera kwatsopano komwe makampani opanga mankhwala angakwaniritse pakuphatikiza mankhwala ndi kupanga mafakitale.Zimabweretsanso malingaliro ochulukirapo azachipatala ndi chithandizo ndi zosankha kwa asing'anga aku China.Tikukhulupirira kuti m'zachipatala zamtsogolo, mankhwala atsopano a chemotherapeutic Eribulin atha kubweretsa chiyembekezo chatsopano kwa odwala khansa ya m'mawere.