Zogulitsa

N(ε)-trifluoroacetyl-L-lysine ndi chochokera ku amino acid lysine, komwe gulu la epsilon (ε) la amino limatetezedwa ndi gulu la trifluoroacetyl (TFA).Kapangidwe kameneka kamapeza ntchito m'madera osiyanasiyana, makamaka mu kaphatikizidwe ka peptide ndi kafukufuku wamankhwala achilengedwe.Kugwiritsa ntchito kwakukulu kwa N (ε) -trifluoroacetyl-L-lysine kuli mu solid-phase peptide synthesis (SPPS).Ma peptides amagwira ntchito yofunika kwambiri pazamoyo zambiri, ndipo kaphatikizidwe kake kamafuna kusanja kotsatizana kwa ma amino acid.Gulu loteteza la TFA pa gulu la epsilon amino la lysine limalepheretsa zochitika zosafunikira panthawi yopanga ma peptide pomwe imalola ma amino acid ena kuti agwirizane pamalo omwe akufuna.Kusonkhana kwa peptide kukamalizidwa, gulu loteteza la TFA likhoza kuchotsedwa mwachisawawa, ndipo zotsalira za N(ε)-trifluoroacetyl-L-lysine zitha kutalikitsidwa kuti ziphatikize mapeptidi otsatizana.N(ε) -trifluoroacetyl-L-lysine ndi amagwiritsidwa ntchito pofufuza za biochemical kuphunzira kapangidwe ka mapuloteni, ntchito, ndi kuyanjana.Itha kukhala ngati chida chofufuzira ntchito ya zotsalira za lysine pakulumikizana kwa mapuloteni-mapuloteni, kulumikizana kwa protein-DNA, ndikusintha pambuyo pomasulira.Poyambitsa gulu la TFA, mankhwala a lysine amatha kusinthidwa, kulola kufufuza kwa ndondomeko yeniyeni ya lysine-mediated m'zinthu zamoyo. machitidwe operekera mankhwala.Ndi conjugating enieni achire wothandizila lysine zotsalira kudzera TFA gulu, n`zotheka kuonjezera bata ndi selectivity wa mankhwala, zomwe zimachititsa kumatheka lapamwamba ndi kuchepetsa mavuto.Njirayi yafufuzidwa popereka mankhwala oletsa khansa, maantibayotiki, ndi mankhwala ena ochiritsira.Kuphatikiza pa ntchito zake zachindunji, N (ε) -trifluoroacetyl-L-lysine ingagwiritsidwenso ntchito ngati chomangira cha kaphatikizidwe ka mankhwala ena ogwira ntchito. .Kapangidwe kake kapadera ka mankhwala ndi reactivity imapangitsa kuti ikhale yoyambira bwino kapena yapakatikati pakuphatikizika kwa mamolekyu ovuta, kuphatikiza mankhwala, agrochemicals, ndi zida. kutsatira njira zoyenera zotetezera.Ndibwino kuti tizigwira ntchito mu labotale yolowera mpweya wabwino ndikugwiritsa ntchito zida zoyenera zodzitetezera, monga magolovesi ndi magalasi oteteza chitetezo. Mwachidule, N(ε) -trifluoroacetyl-L-lysine ndi chochokera ku lysine chomwe chimapeza ntchito zosiyanasiyana mu peptide. kaphatikizidwe, kafukufuku wamankhwala amthupi, kuperekera mankhwala omwe akuwunikiridwa, komanso kaphatikizidwe ka organic.Kuthekera kwake kuteteza gulu la epsilon amino la lysine kumathandizira kaphatikizidwe kake ka peptide, pomwe mawonekedwe ake osinthika amalola kuphunzira njira za lysine-mediated.Ikagwiridwa bwino, N(ε)-trifluoroacetyl-L-lysine imatsimikizira kukhala chida chothandiza pa ntchito zosiyanasiyana za sayansi ndi mafakitale.