Zogulitsa

Methyl 4-(4-Fluorophenyl) -6-Isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate, yomwe imadziwikanso kuti Z6, ndi pawiri yomwe ingagwiritsidwe ntchito mosiyanasiyana m'munda wamankhwala. .Kupezeka kwa gulu la phenyl lolowetsedwa m'malo mwa fluoro lomwe limagwirizanitsidwa ndi mphete ya pyrimidine limasonyeza kuti Z6 ikhoza kuyanjana ndi zolinga zamoyo, zomwe zimapangitsa kuti zikhale zodalirika zoyesa kupeza mankhwala.Kuphatikizika kwa gulu la isopropyl kumawonjezera hydrophobicity ya pawiri, zomwe zimatha kupititsa patsogolo luso lake lolowera m'mitsempha yazachilengedwe ndikufika pamalo omwe akufuna. Mbali ina yofunika kwambiri ya Z6 ndi kukhalapo kwa gulu la amino la N-methyl-N-methylsulfonyl.Gulu logwira ntchitoli lakhala likugwirizana ndi kupititsa patsogolo kukhazikika kwa kagayidwe kachakudya komanso kuchepetsa zomwe zingachitike.Zitha kuthandizanso kusungunuka kwapawiri m'malo ozungulira.Zinthuzi zingakhale zamtengo wapatali pakupanga mankhwala a bioactive.Kupezeka kwa gulu la methyl ester mu Z6 kumapereka muyeso wokhazikika komanso wosavuta kusamalira.Kuonjezera apo, gulu la carboxylate lomwe lili pa 5-position ya mphete ya pyrimidine likhoza kukhala malo omwe angapangidwe kusintha kwa mankhwala, kulola maphunziro a ubale-ntchito ndi kukhathamiritsa kwa mankhwala a mankhwala. zopangira (API) zochizira matenda osiyanasiyana.Itha kufufuzidwa chifukwa cha kuthekera kwake ngati anti-inflammatory agent, antiviral mankhwala, kapena mu chithandizo cha khansa.Kuphatikizika kwapadera kwa magulu ogwira ntchito kungapereke mwayi wosankha kuyanjana kwachilengedwe, ndikupangitsa kuti ikhale yosangalatsa yosintha chandamale chamankhwala.Kuphatikizansopo, kusiyanasiyana kwa mapangidwe a Z6 kumapangitsa kukhala kosangalatsa koyambira pakupanga malaibulale ang'onoang'ono a mamolekyu kapena ma scaffolds amankhwala.Itha kukhala ngati chomangira chophatikizira zotengera zosiyanasiyana, zomwe zimathandizira kuwunika kwa maubwenzi ndi magwiridwe antchito ndikuzindikiritsa zida zotsogola kuti zipititse patsogolo kukhathamiritsa. zosiyanasiyana mankhwala ntchito.Kuthekera kwake ngati API, kuphatikiza kusinthasintha koyenera kusinthidwa ndi kukhathamiritsa, kumapangitsa kuti ikhale yosangalatsa pakupeza mankhwala ndi ntchito zachitukuko.Maphunziro owonjezera ndi kufufuza ndizofunikira kuti mufufuze mokwanira ndikugwiritsira ntchito mphamvu zake zothandizira.