Zogulitsa

Njira zochizira T2DM, matenda omwe amadziwika ndi kuwonongeka kwapawiri kwa islet cell komanso kukana insulini, amaphatikizanso mankhwala omwe amawonjezera kutulutsa kwa insulin ndi kapamba (secretagogues), othandizira omwe amawonjezera chidwi cha ziwalo zomwe zimakhudzidwa ndi insulin (zolimbikitsa), ndi Liraglutide, GLP-1 receptor agonist kuti afike kumsika, ali ndi 97% homology ku GLP-1 ndi zosintha ziwiri zokha za amino acid komanso kuwonjezera kwa unyolo wammbali wamafuta acid.Mwachindunji, lysine yomwe ili pamalo 34 yasinthidwa ndi arginine, ndipo lysine yomwe ili pa malo 26 yasinthidwa ndi tcheni cha C16 acyl kudzera mu spacer ya glutamoyl.Liraglutide imapeza kukana kwake ku kuwonongeka kwa DPP-4 kuchokera pakukonda kwake kupanga ma micelles ndikumanga ku albumin.Mosiyana ndi omwe adayambitsa exenatide, omwe amafunikira jakisoni wocheperako kawiri tsiku lililonse musanadye chakudya choyamba komanso chomaliza chatsiku, liraglutide imavomerezedwa ngati njira yochizira kamodzi patsiku ndipo itha kugwiritsidwa ntchito limodzi ndi metformin kapena sulfonylurea mwa odwala omwe ali ndi vuto lowongolera glycemic. monotherapy kapena kuphatikiza wapawiri mankhwala.Amavomerezedwanso kuphatikiza ndi chithandizo chapawiri cha metformin ndi thiazolidinedione mwa odwala omwe ali ndi vuto lowongolera glycemic.Liraglutide adawonetsa mphamvu yomangirira ya 61 pM (EC50 = 55 pM ya GLP-1) kwa cholandilira cha GLP-1 chamunthu.