Zogulitsa

Ma peptides okhala ndi kubwereza 8 kwa aspartate-serine-serine (8DSS) awonetsedwa kuti amalimbikitsa nucleation ya calcium phosphate kuchoka mu yankho kukhala enamel yamunthu.Apa tidayesa kuthekera kwa 8DSS kulimbikitsa kukonzanso kwa enamel yopangidwa ndi demineralized mu in vitro model of artificial early enamel caries.Zilonda zoyamba za caries zidapangidwa mu midadada ya bovine enamel, yomwe kenako idayikidwa pa 12 d ya pH panjinga pamaso pa 25 µM 8DSS, 1 g/L NaF (positive control) kapena buffer yokha (yoyipa kuwongolera).Mayamwidwe a 8DSS adatsimikiziridwa ndi X-ray photoelectron spectroscopy.Kutayika kwa minerals, kuya kwa zilonda, ndi mchere wamchere pamtunda ndi kuya kosiyana kwa thupi lotupa linawunikidwa isanayambe kapena itatha pH njinga pogwiritsa ntchito polarized light microscopy ndi transverse microradiography.Kutayika kwa mchere pambuyo pa kuyendetsa pH kunali kochepa kwambiri mu zitsanzo za 8DSS kusiyana ndi zitsanzo za buffer-okha, ndipo zotupa mu zitsanzo za 8DSS zinali zochepa kwambiri.Zitsanzo zothandizidwa ndi 8DSS zidawonetsa kuchuluka kwa mchere kuposa zitsanzo zokhala ndi malo okhawo m'chigawo chochokera kumtunda (30 µm) kupita kukuya kwapakati (110 µm).Palibe kusiyana kwakukulu komwe kunapezeka pakati pa zitsanzo zothandizidwa ndi 8DSS ndi omwe amathandizidwa ndi NaF.Zotsatirazi zikuwonetsa kuti 8DSS imatha kulimbikitsa kukonzanso kwa enamel ya demineralized.