Zogulitsa

Ornithine aspartate inali yoyamba kugwiritsidwa ntchito kuchipatala pochiza chimfine ndi hepatic encephalopathy.Pakuchulukirachulukira kwa chidziwitso chamankhwala, ornithine aspartate yakhala ikugwiritsidwa ntchito kwambiri pochiza matenda a chiwindi, ndipo yapeza zotsatira zenizeni zochiritsira pa hepatic encephalopathy, kuwonongeka kwa chiwindi chifukwa cha mankhwala, chiwindi chamafuta, matenda a chiwindi ndi matenda ena. odziwika ndi madokotala.

Ornithine aspartate imapereka gawo lapansi la urea ndi glutamine synthesis mu vivo.Glutamine ndi mankhwala ochotsera ammonia, komanso kusungirako ndi kunyamula ammonia.Pansi pa zochitika zakuthupi ndi zakuthambo, kaphatikizidwe ka urea ndi kaphatikizidwe ka glutamine kumakhudzidwa ndi ornithine, aspartic acid ndi mankhwala ena a dicarboxyl.Ornithine imakhudzidwa pafupifupi njira yonse yotsegulira urea ndikuchotsa ammonia.Arginine amapangidwa panthawiyi, ndipo urea amapatulidwa kuti apange ornithine.Aspartic asidi nawo synthesis wa nucleic asidi mu hepatocytes kuti atsogolere kukonza kuonongeka hepatocytes.Kuphatikiza apo, chifukwa cha kukwezedwa kwachindunji kwa aspartic acid pamayendedwe a metabolic a tricarboxylic acid mkombero m'maselo a chiwindi, amalimbikitsa kaphatikizidwe kamphamvu m'maselo a chiwindi, omwe amathandizira kukonza ma cell owonongeka a chiwindi ndikufulumizitsa kuchira kwa chiwindi.Kupita patsogolo kwaposachedwa kwawonetsa kuti aspartate imathanso kulepheretsa ntchito ya inflammasomes kudzera mu ma receptors a N-methyl-D-aspartate (NMDA), potero amachepetsa njira yamankhwala yoyankha kutupa kwa chiwindi.NMDA zolandilira ndi kagawo kakang'ono ka ionotropic excitatory glutamate receptors, zomwe zimagwira ntchito yofunika kwambiri pazathupi monga kufala kwa synaptic, synaptic plasticity, kuphunzira ndi kukumbukira mkati mwa dongosolo lamanjenje.Kafukufuku wotsatira wa pathological adatsimikiziranso kuti aspartate imathandizira kwambiri zotupa zotupa m'chiwindi.

Kugwiritsa ntchito kuchipatala

M'munda wa matenda a chiwindi: Ornithine aspartate chimagwiritsidwa ntchito ngati odana ndi kutupa ndi hepatoprotective mankhwala pa matenda a chiwindi matenda osiyanasiyana, monga kwa chiwindi encephalopathy, mankhwala ochititsa chiwindi kuwonongeka, mafuta chiwindi, aakulu chiwindi, etc. magazi ammonia odwala encephalopathy ndi mpumulo wa zizindikiro neuropsychiatric pang'onopang'ono kukhala waukulu achire mankhwala zochizira matenda osiyanasiyana a chiwindi.

Ornithine aspartate ndi gawo lapansi lofunikira pakuphatikizika kwa urea ndi glutamine.Ornithine akhoza yambitsa michere kiyi mu ndondomeko urea kaphatikizidwe - ornithine carbamoyltransferase ndi carbamoyl mankwala synthase, ndi kulimbikitsa ammonia kagayidwe kake kukwaniritsa detoxification wa magazi ammonia, aspartic asidi monga gawo lapansi akhoza kupanga glutamic acid ndi oxaloacetic acid, detoxification ndi mankhwala detoxification. ammonia, komanso ndi kusunga ndi kunyamula ammonia.Oxaloacetate imatenga nawo gawo mu tricarboxylic acid cycle, imalimbikitsa kupanga mphamvu m'maselo a chiwindi, ndipo imathandizira maselo owonongeka a chiwindi kuti akonzedwe, kusinthidwa, ndi kubwezeretsa ntchito ya chiwindi.Ornithine aspartate akhoza bwino kusintha chiwindi ntchito, kuchepetsa magazi ammonia, ndi synergistically kuchepetsa ammonia ndi lactulose ndi ofloxacin, potero kwambiri kusintha mlingo wa mankhwala kwa kwa chiwindi encephalopathy, amene ali woyenera kuchipatala ntchito.

Oncology: Ndi kusintha kosalekeza kwa mitundu ndi Mlingo wa mankhwala a chemotherapy, zovuta zomwe zimagwirizanitsidwa ndi mankhwala a chemotherapy zimayambanso, ndipo kuwonongeka kwa chiwindi ndi chimodzi mwazowonongeka za chiwalo.Chiwindi chikawonongeka, zimakhudza thanzi ndi malingaliro a odwala mosiyanasiyana, kulepheretsa kukhazikitsidwa kwa ma regimens a chemotherapy, ndikufooketsa chithandizo chamankhwala.Zikavuta kwambiri, kulephera kwa chiwindi kumatha kuyika moyo pachiwopsezo.Ornithine aspartate imatha kusintha kwambiri kuwonongeka kwa chiwindi chifukwa cha mankhwala a chemotherapy ndikuwongolera chithandizo cha odwala chotupa.

Opaleshoni ya Opaleshoni: Opaleshoni imawomba ziwalo zonse za thupi la wodwalayo, ndipo kuwonongeka kwa chiwindi pambuyo pa opaleshoni ndizovuta kwambiri.Ornithine aspartate imatha kuteteza ndi kuchiza kuwonongeka kwa chiwindi pambuyo pa opaleshoni ndikulimbikitsa kuchira kwa odwala.