Zogulitsa

Idiopathic pulmonary fibrosis imaganiziridwa kuti imakhudza kuvulala kwamapapo komwe kumachitika chifukwa cha mtundu wa oxygen (ROS), womwe umatsatiridwa ndi fibrosis yosadziwika bwino.Kusintha kwa kukula kwa chinthu (TGF) -β1-kuwonjezeka kwa chiwerengero cha myofibroblast kumathandiza kwambiri mu fibrosis yodabwitsayi.Posachedwapa tapeza kuti mepenzolate bromide (mepenzolate), yomwe yakhala ikugwiritsidwa ntchito kuchipatala pochiza matenda a m'mimba, ili ndi mphamvu zochepetsera ROS.Pakafukufuku wapano, tawona momwe mepenzolate imakhudzira bleomycin-induced pulmonary fibrosis ndi kusagwira ntchito kwamapapo mu mbewa.Kuopsa kwa pulmonary fibrosis kunayesedwa ndi kuwunika kwa histopathological ndi kutsimikiza kwa milingo ya hydroxyproline.Makina a m'mapapo (elastance) ndi ntchito ya kupuma [kukakamiza kofunikira mphamvu (FVC)] adawunikidwa pogwiritsa ntchito chowongolera choyendetsedwa ndi kompyuta.Ntchito yopuma idawunikidwanso poyang'anira percutaneous arterial oxygen saturation (SpO2).Kuwongolera m'mitsempha ya mepenzolate musanayambe chithandizo cha bleomycin kunachepetsa kuchuluka kwa pulmonary fibrosis ndi kusintha kwa makina a m'mapapo ndipo kunachititsa kuti FVC ndi SpO2 zichiritsidwe kwambiri poyerekeza ndi kulamulira.Kuphatikiza apo, mepenzolate idapanga chithandizo chamankhwala ngakhale idaperekedwa pambuyo pakukula kwa fibrosis.Kuwongolera kwa mepenzolate kunalepheretsanso kufa kwa maselo am'mapapo a bleomycin ndi mayankho otupa komanso kuchuluka kwa myofibroblast.Mepenzolate inachepetsanso ntchito ya NADPH oxidase ndi mlingo wa TGF-β1 yogwira ntchito kapena kuwonjezeka kwa glutathione S-transferase (GST) pamaso pa mankhwala a bleomycin.Zotsatira izi zikuwonetsa kuti intracheal management ya mepenzolate idachepetsa bleomycin-induced pulmonary fibrosis komanso kusagwira bwino ntchito kwamapapu mu mbewa.Zotsatirazi zitha kukhala chifukwa cha kulepheretsa kwa mankhwalawa pa NADPH oxidase ndi ntchito za TGF-β1 komanso zotsatira zake zolimbikitsa pa GST.