Zogulitsa

EAAT2 glutamate transporter, amawerengera>90% ya hippocampal glutamate.Ngakhale EAAT2 imawonetsedwa makamaka mu zakuthambo, ~10% ya mamolekyu a EAAT2 amapezeka mu ma axon terminals.Ngakhale kutsika kwa mawu a EAAT2 m'ma terminal a glutamatergic, magawo a hippocampal akalumikizidwa ndi kutsika kwa d-aspartate (gawo laling'ono la EAAT2), ma axon terminals amapeza d-aspartate mwachangu ngati astroglia.Izi zikutanthawuza kusagwirizana kosadziwika bwino pakati pa kugawidwa kwa mapuloteni a EAAT2 ndi zochitika zoyendera za EAAT2.Lingaliro limodzi ndiloti (1) Kusinthanitsa kwapakati kwa gawo lapansi ndi gawo lakunja kumathamanga kwambiri kuposa kutengeka ndi ukonde ndipo (2) ma terminals amakonda kusinthanitsa chifukwa cha kuchuluka kwa glutamate mkati.Komabe, sizikudziwika ngati heteroexchange ndi kutengeka kuli ndi mitengo yofanana kapena yosiyana.Kuti tithane ndi vutoli, tidagwiritsa ntchito njira yokhazikitsidwanso kuti tifananize mitengo yofananira yanjira ziwirizi mu makoswe ndi mbewa.Net uptake idakhudzidwa ndi kusintha kwa nembanemba yomwe imatha ndipo idalimbikitsidwa ndi ma anion akunja ovomerezeka mogwirizana ndi kukhalapo kwa ma anion osagwirizana.Pogwiritsa ntchito chomaliza, tikuwonetsanso kuti kuchuluka kwa heteroexchange kumadaliranso kuthekera kwa nembanemba.Kuphatikiza apo, zambiri zathu zikuwonetsanso kukhalapo kwa kutayikira kwa sodium mu EAAT2.Pophatikiza zomwe tapeza mu mtundu wathu wam'mbuyomu wa glutamate uptake ndi EAAT2, timalosera kuti mphamvu yamagetsi yamagetsi yosinthira imayamba chifukwa chomangika kwachitatu kodalira Na(+).Kupitilira apo, zoyeserera zathu zonse komanso zofananira zikuwonetsa kuti mitengo yotengera ukonde ndi heteroexchange ikufanana ndi EAAT2.