Zogulitsa

Flucytosine, wotchedwanso 5-fluorocytosine kapena 5-FC, ndi kupanga antifungal mankhwala amene makamaka ntchito zochizira matenda mafangasi.Imawerengedwa kuti ndi antimetabolite, zomwe zikutanthauza kuti imasokoneza kagayidwe kachakudya m'maselo a mafangasi, zomwe zimapangitsa kuti atsekedwe kapena kufa.Flucytosine nthawi kutumikiridwa osakaniza antifungal wothandizila mulingo woyenera kwambiri efficacy.Mmodzi wa ntchito kiyi flucytosine ndi zochizira matenda mafangasi, makamaka amene amayamba ndi mitundu Candida ndi Cryptococcus.Nthawi zambiri amagwiritsidwa ntchito limodzi ndi antifungal wothandizira, monga amphotericin B kapena fluconazole, kuti apititse patsogolo ntchito yake ya antifungal.Flucytosine imagwira ntchito polowa m'maselo a mafangasi ndikusintha kukhala 5-fluorouracil, cytotoxic antimetabolite.5-fluorouracil ndiye imasokoneza kaphatikizidwe wa mafangasi a RNA ndi DNA, potero amalepheretsa kukula kwa mafangasi ndi kubwerezabwereza.Njira yolumikizirana imeneyi imathandiza kuthana ndi matenda ambiri a mafangasi ndikuwonjezera mphamvu yamankhwala.Kugwiritsa ntchito kwina kofunikira kwa flucytosine ndikuchiza Cryptococcus neoformans meningitis, matenda omwe amatha kupha moyo omwe amakhudza nembanemba zozungulira ubongo ndi msana.Flucytosine imatengedwa kuti ndi imodzi mwa njira zochiritsira zoyambirira kuphatikiza ndi amphotericin B zochizira matendawa.Kuphatikiza mankhwala kumathandiza kuthana ndi malire a mankhwala aliwonse okha ndikupeza machiritso apamwamba.Flucytosine kufika misinkhu yokwanira mu cerebrospinal madzimadzi, kulola kuti bwino akulimbana ndi matenda mafangasi chapakati mantha system.Flucytosine Angagwiritsidwenso ntchito zochizira matenda ena mafangasi, monga matenda chifukwa cha mitundu ina ya Candida ndi Aspergillus.Komabe, kugwiritsidwa ntchito kwake kungakhale kochepa chifukwa cha chiopsezo chokhala ndi kukana, monga bowa amatha kupeza masinthidwe omwe amachititsa kuti asatengeke ndi mankhwalawa.Kuwunika kwapafupi ndi kufufuza nthawi ndi nthawi kwa chithandizo chamankhwala ndikofunikira mukamagwiritsa ntchito flucytosine kuti muwonetsetse zotsatira zoyenera zamankhwala.Ngakhale kuti flucytosine nthawi zambiri imalekerera bwino, imatha kukhala ndi zotsatirapo zoyipa.Zotsatira zodziwika bwino zimaphatikizapo kusokonezeka kwa m'mimba, monga nseru, kusanza, ndi kutsekula m'mimba.Zingayambitsenso kuponderezedwa kwa mafupa, zomwe zingapangitse kuti maselo a magazi achepe.Nthawi zambiri kuyezetsa magazi kumachitika kuti aziyang'anira kuchuluka kwa maselo a magazi panthawi ya chithandizo.Mwachidule, flucytosine ndi mankhwala oletsa tizilombo toyambitsa matenda omwe amagwiritsidwa ntchito pochiza matenda a fungal, makamaka omwe amayamba chifukwa cha Candida ndi Cryptococcus mitundu.Imachita ndikusokoneza kaphatikizidwe ka fungus nucleic acid, kulepheretsa kukula kwawo ndi kubwerezabwereza.Flucytosine amagwiritsidwa ntchito mowirikiza limodzi ndi mankhwala ena oletsa kutupa ndipo ndiyofunikira kwambiri pochiza Cryptococcus neoformans meningitis.Komabe, kugwiritsidwa ntchito kwake kumafuna kuyang'anitsitsa mosamala chifukwa cha chiopsezo cha kukana ndi zotsatira zake zoipa.