Zogulitsa

Kutupa kosalekeza kwanjira yapamlengalenga ndi kukonzanso, kuphatikiza fibrosis, zanenedwa kuti ndizothandizira kwambiri pathophysiology ya mphumu.Maphunziro am'mbuyomu a airway fibrosis adachitidwa makamaka mu asthmatics yofatsa komanso yocheperako pamlingo wa subpithelial "basement membrane" (SBM).Kafukufuku wapano adapangidwa kuti ayese makulidwe akulu amtundu wa SBM ndi submucosal collagen deposition, monga momwe amayesedwera ndi njira zitatu zothimbirira za collagen, mu endobronchial biopsies kuchokera ku 17 yoopsa, zisanu ndi zinayi zofatsa, ndi zisanu ndi ziwiri zofatsa za asthmatics, komanso maphunziro asanu ndi atatu owongolera.Tissue eosinophils ndi transforming growth factor-beta (TGF-beta) immunoreactivity anayesedwanso.Panalibe kusiyana kwakukulu kwa chiwerengero cha SBM makulidwe, submucosal collagen deposition, eosinophil manambala, kapena TGF-beta maselo abwino pakati pa magulu atatu a asthmatics ndi maphunziro olamulira.Zinali pokha pofufuza asthmatics yonse (n = 33) palimodzi, pomwe SBM yokhuthala pang'ono (p = 0.04), monga momwe idawunikiridwa ndi collagen mtundu wa III immunostaining, idawonedwa poyerekeza ndi maphunziro owongolera.Ngakhale kusiyana kumeneku, palibe kusiyana kwakukulu komwe kunapezeka mu kuchuluka kwa submucosal collagen deposition ndi chiwerengero cha eosinophils kapena TGF-beta yosonyeza maselo poyerekezera asthmatics ndi maphunziro abwinobwino.Kuphatikiza apo, palibe kulumikizana kwakukulu komwe kunapezeka pakati pa collagen deposition ndi eosinophil count, TGF-beta expression level, FEV1, kapena nthawi ya mphumu.Zotsatirazi zikusonyeza kuti ngakhale kuti kuwonjezeka kwa collagen mu SBM pamtunda waukulu wa mpweya ndi khalidwe la mphumu, sizingafotokoze kusiyana kwa kuopsa kwa mphumu.