Doxorubicin hydrochloride CAS: 25316-40-9 99% ufa wa crystalline wofiira
| Nambala ya Catalog | XD90367 |
| Dzina lazogulitsa | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Molecular Formula | C27H29NO11·HCl |
| Kulemera kwa Maselo | 579.98 |
| Zambiri Zosungira | 2 mpaka 8 ° C |
| Harmonize Tariff Code | 29419000 |
Mafotokozedwe a Zamalonda
| MadziZamkatimu | ≤ 4.0% |
| pH | 4.0-5.5 |
| Kusungunuka | Zosungunuka mu: madzi, methanol ndi isotonic NaCl(aq).Kusasungunuka kwa chloroform ndi zosungunulira zina za organic. |
| Zogwirizana nazo | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Kuyesa | 99% |
| Zosungunulira Zotsalira | Acetone ndi mowa: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Zonyansa Zina Zilizonse | ≤ 0.5% |
| Zonse Zonyansa | ≤ 2.0% |
| Crystallinity | Imagwirizana ndi USP |
| Maonekedwe | Mtundu wofiira wa Crystalline ufa |
| Chizindikiritso | Mtengo wa HPLC |
Odwala omwe ali ndi P-glycoprotein ndi HER2/neu (HER2) receptor-overexpressing khansa ya m'mawere nthawi zambiri amakhala ndi zotsatira zoyipa zachipatala.Komabe, palibe mizere yama cell a khansa ya m'mawere yomwe imapezeka pamalonda yomwe ili ndi HER2/P-glycoprotein yawiri, zomwe zimalepheretsa kafukufuku pankhaniyi. cell cell line by stable transfection of the ATP-binding cassette (ABC) subfamily B membala 1 (ABCB1) jini yomwe imatsekera P-glycoprotein.ABCB1 gene expression expression is above transfection, zomwe zinapangitsa kuti P-glycoprotein ichuluke ka 40. mawu.Chochititsa chidwi n'chakuti, kupatsirana kwa ABCB1 kunapangitsanso kuwonjezeka pang'ono kwa HER2 jini ndi mafotokozedwe a mapuloteni.Kupatsirana kwa ABCB1 kunachulukitsa kuchuluka kwa mawu a P-glycoprotein kwambiri.Njira yomwe imagwiritsidwa ntchito pano popanga selo ili ndi yoyenera kuti ikhale yofulumira, yokhazikika ya P-glycoprotein-mediated drug resistance poyerekeza ndi tr aditional njira.Mayeso a in vitro cytotoxicity akuwonetsa kuti mzere wa cellwu umalimbana ndi mitundu ingapo ya mankhwala a chemotherapeutic.
