Zogulitsa

Kuchita bwino kwa mamolekyu opha maantibayotiki pochiza chibayo cha Pseudomonas aeruginosa kumachepetsedwa chifukwa cha kufalikira kwa kukana kwa mabakiteriya.Kukhalapo kwa njira zolankhulirana ndi mabakiteriya, monga kuzindikira quorum, kwapereka mwayi watsopano wamankhwala.Lactonases amathimitsa bwino ma acyl-homoserine lactone-based bacterial quorum sensing, kutanthauza kuti ma enzymes awa ndi mankhwala atsopano odana ndi Pseudomonas omwe angawunikidwe ndi chibayo. Kufa kwa khoswe P. aeruginosa chibayo. Kuti tiwunikire kuchuluka kwa SsoPox-I-mediated quorum, tinayesa kaye ntchito ya jini lasB ya virulence, kaphatikizidwe ka pyocianin, ntchito ya proteolytic ya kuyimitsidwa kwa bakiteriya ndi mapangidwe a biofilm a PAO1 strain wokulirapo pamaso pa lactonase.Muchitsanzo choopsa kwambiri cha P. aeruginosa chibayo mu makoswe, tinawona zotsatira za chithandizo cham'mbuyo kapena chochedwetsa chapakati pa tracheal ndi SsoPox-I pa imfa, kuchuluka kwa bakiteriya m'mapapo ndi kuwonongeka kwa mapapo. , kaphatikizidwe ka pyocianin, ntchito ya proteolytic ndi mapangidwe a biofilm.Kugwiritsa ntchito koyambirira kwa SsoPox-I kunachepetsa kufa kwa makoswe okhala ndi chibayo chowopsa kuchokera ku 75% mpaka 20%.Kuwonongeka kwa mapapu a histological kunachepetsedwa kwambiri koma kuchuluka kwa bakiteriya m'mapapo sikunasinthidwe ndi chithandizo.Chithandizo chochedwa chinagwirizanitsidwa ndi kuchepa kosafunikira kwa imfa.Zotsatirazi zikuwonetsa zotsatira zoteteza lactonase SsoPox-I mu P. aeruginosa chibayo ndikutsegula njira yogwiritsira ntchito mankhwala amtsogolo.