Diethylene triamine pentaacetic acid Cas: 67-43-6 99% White crystalline ufa
| Nambala ya Catalog | XD90220 |
| Dzina lazogulitsa | Diethylene triamine pentaacetic acid |
| CAS | 67-43-6 |
| Molecular Formula | C14H23N3O10 |
| Kulemera kwa Maselo | 393.3465 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29224985 |
Mafotokozedwe a Zamalonda
| Zitsulo zolemera | 0.001% kuchuluka |
| pH | 2-3 |
| Fe | 0.001% kuchuluka |
| Kusungunuka | Imasungunuka pang'ono m'madzi, 15% yankho limasungunuka m'madzi otentha.Zosungunuka mu Alkali yonse |
| Kuyesa | 99% mphindi |
| Phulusa la Sulfated | 0.1% kuchuluka |
| Cl | 0.1% kuchuluka |
| Maonekedwe | White crystalline ufa |
Kuwonjezeka kwa kupsinjika kwa okosijeni pansi pa mikhalidwe ya hyperglycemic, kudzera mu kuyanjana kwa AGEs ndi RAGE zolandilira komanso kudzera mu activation ya interleukin mediated transcription signing, zanenedwa mu khansa.Zosintha zamapuloteni zikuwunikidwa chifukwa cha gawo lawo pakukula ndikukula kwa khansa ndipo kuyankha kwa autoantibody motsutsana nawo kukupeza chidwi ngati kafukufuku wowunikira matendawa.Kafukufukuyu adasanthula kusintha kwa histone H1 atasinthidwa ndi methylglyoxal (MG) ndi zotsatira zake mu auto-immunopathogenesis ya khansa.Kusintha kwa histone kunawonetsa kusintha kwa zotsalira zonunkhira, kusintha tyrosine microenvironment, intermolecular cross linking and generation of AGEs.Zinawonetsa kubisala kwa zigamba za hydrophobic komanso kusintha kwa hypsochromic mu ANS fluorescence yeniyeni.MG mwaukali oxidized histone H1 kuchititsa kudzikundikira reactive carbonyls.Miyezo yakutali ya UV CD idawonetsa kukulitsa kwa di-carbonyl kwa kapangidwe ka alpha ndi kulowetsedwa kwa ma sheet a beta;ndi maphunziro a denaturation (Tm) amatsimikizira kukhazikika kwa kutentha kwa histone yosinthidwa.Kusanthula kwa FTIR kunawonetsa kusintha kwa amide I band, m'badwo wa gulu la carboxyethyl ndi kugwedezeka kwa N-Cα mu histone yosinthidwa.Kusanthula kwa LCMS kunatsimikizira kupangidwa kwa Nε-(carboxyethyl) lysine ndi maphunziro a electron microscopic adawonetsa kupanga kwa amorphous aggregate.Histone yosinthidwa idawonetsa kusinthika kogwirizana ndi DNA.Kusinthidwa kwa H1 kunapangitsa ma antibodies apamwamba kwambiri mu akalulu ndipo IgG yodzipatula sera ya akalulu otetezedwa ndi H1 yosinthidwa adawonetsa kumangiriza kwake ndi ma immunogen pakuwunika kwa Western Blot.IgG yotalikirana ndi sera ya odwala omwe ali ndi khansa ya m'mapapo, khansa ya prostate, khansa ya m'mawere ndi khansa ya mutu ndi khosi adawonetsa kuzindikira bwino kwa neo-epitopes pa histone yosinthidwa, kuwonetsa kupezeka kwa autoantibodies mu khansa.Popeza malipoti akuwonetsa kulumikizana pakati pa AGE-RAGE axis ndi carcinogenesis, glycoxidation ya histone H1 ndi immunogenicity yake imatsegula njira zomvetsetsa gawo la mapuloteni a nyukiliya owonongeka ndi glycoxidative mu khansa.
