Zogulitsa

Kukhudzidwa koyipa ndikofunikira kuti pakhale chiwopsezo cha chizolowezi cha opiate monga momwe zimasonyezedwera ndi kuchuluka kwa nkhanza kwa opiate ndi vuto lalikulu lachisokonezo (MDD).Mitundu ya makoswe imakhudza amygdala prodynorphin (Pdyn) ngati mkhalapakati wazovuta zoyipa;komabe, umboni wa kukhudzidwa kwa PDYN pakukhudzidwa koyipa kwa anthu ndi kochepa.Apa, tapeza kuchepetsedwa kwa mawu a PDYN mRNA mu postmortem human amygdala nucleus ya periamygdaloid cortex (PAC) mwa onse ozunza heroin ndi maphunziro a MDD.Mofanana ndi anthu, makoswe omwe adadzipangira okha heroin adachepetsa mawu a Pdyn mRNA mu PAC panthawi yokhudzana ndi vuto loipa.Pogwiritsa ntchito luso lojambula mu vivo lothandizira DREAMM (DREADD-assisted metabolic mapu, pomwe DREADD ikuwonetsa zolandilira opanga amapangidwa ndi mankhwala opangira), tidapeza kuti kuletsa kosankha kwa Pdyn-expressing neurons mu makoswe PAC kumawonjezera zochitika za metabolic mu amygdala yotalikirapo, yomwe. ndi gawo lofunikira la dongosolo la extrahypothalamic brain stress.Mofananamo, kuletsa kwa Pdyn kwapadera kwa PAC kudayambitsa kusintha kokhudzana ndi thupi ndi kakhalidwe.Zonsezi, kafukufuku wathu womasulira amathandizira gawo la Pdyn yemwe ali ndi vuto la PAC mu nkhanza za opiate kudzera mu kuyambitsa kupsinjika komanso kusokoneza ma neurocircuitry omwe ali pachiwopsezo chazolowera.