Zogulitsa

Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ndi mankhwala pawiri kuti amapeza ntchito m'munda wa chemistry mankhwala ndi chitukuko cha mankhwala.Mapangidwe ake a maselo amakhala ndi mphete ya pyrrolidine yokhala ndi gulu la tert-butyl pamalo a cis, gulu la ethyl, ndi magulu awiri a carboxylate.Pawiri iyi imapezeka mu mawonekedwe a mchere wa hydrochloride. Chimodzi mwazinthu zazikulu zogwiritsira ntchito cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ndi kaphatikizidwe ndi chitukuko cha mankhwala olunjika chapakati. dongosolo lamanjenje (CNS).Kukhalapo kwa mphete ya pyrrolidine, pamodzi ndi magulu a tert-butyl ndi ethyl, kumapereka chigawo ichi chokhala ndi mphamvu zowonongeka.Ofufuza atha kugwiritsa ntchito pawiri ngati poyambira kupanga ma analogi kapena zotumphukira zomwe zitha kuyanjana ndi ma receptor kapena ma enzymes mu CNS.Mwa kusintha kapangidwe kake ndi zolowa m'malo, amatha kukhathamiritsa katundu wa pharmacokinetic, kukulitsa kuyanjana kwake ndi cholandilira, ndikusintha mphamvu zake zochizira. Komanso, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ikhoza kukhala amagwiritsidwa ntchito ngati chida chophatikizira m'maphunziro achilengedwe kuti afufuze momwe ma receptor kapena ma enzymes amagwirira ntchito mu minyewa.Pogwiritsa ntchito mankhwalawa ngati ligand kapena probe, ofufuza amatha kuphunzira momwe amamangirira, kusankha, ndi njira zogwirira ntchito za zolandilira kapena ma enzymes.Chidziwitsochi ndichofunika kwambiri kuti timvetsetse momwe ma cell a ma neuropharmacological process amapangidwira komanso kupanga njira zatsopano zochiritsira zomwe zimayang'ana matenda a neurodegenerative, misala, kapena matenda a minyewa.Itha kuphatikizidwa m'malaibulale azinthu, omwe amawunikiridwa motsutsana ndi zolinga zosiyanasiyana, monga zolandilira kapena ma enzymes, kuti azindikire zomwe zingatsogolere kapena ofuna kumwa mankhwala.Kuwunika kumeneku kumapangitsa kuti azindikire mankhwala omwe amawonetsa zofunikira za mankhwala kapena zotsatira zochiritsira.Kuonjezera apo, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride angapeze zothandiza pakupanga mankhwala osokoneza bongo.Mankhwalawa ndi osagwira ntchito kapena ocheperapo omwe amapangidwa kuti apangidwe mu mawonekedwe awo akugwira ntchito kamodzi mkati mwa thupi.Posintha kapangidwe ka kaphatikizidwe kameneka, ofufuza amatha kupanga mitundu yokhazikika yokhazikika, yopititsa patsogolo bioavailability, kapena amatha kudutsa nembanemba zachilengedwe mosavuta.Mwachidule, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ndi pawiri ndi kuthekera ntchito pa chitukuko cha CNS chandamale mankhwala. , monga chida chothandizira maphunziro a zamoyo, kupeza mankhwala, ndi kupanga mankhwala.Mapangidwe ake apadera a maselo amapereka mwayi wosinthidwa ndi kukhathamiritsa kuti apititse patsogolo mphamvu zake zamankhwala ndi zochitika zachilengedwe.Kusinthasintha komanso kuthekera kwapawiriyi kumapangitsa kuti ikhale yofunika kwambiri pazamankhwala amankhwala komanso chitukuko chamankhwala.