Zogulitsa

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) ndi carboxypeptidase yokhala ndi zinc ndipo imalepheretsa kwambiri fibrinolysis.Chifukwa chake, TAFIa inhibitors akuyembekezeka kukhala ngati profibrinolytic agents.Posachedwapa tinanena za mapangidwe ndi kaphatikizidwe ka selenium-containing inhibitors a TAFIa ndi ntchito yawo yoletsa.Apa tikunena za mawonekedwe a kristalo a selenium-, sulfure-, ndi phosphinic acid-containing inhibitors omwe amamangidwa ku porcine pancreatic carboxypeptidase B (ppCPB).ppCPB ndi TAFIa homologue ndipo ndi TAFIa yolowera m'malo mwa crystallographic kusanthula.Makristalo a ppCPB opangidwa ndi selenium compound 1a, sulfure analogue 2, ndi phosphinic acid yochokera EF6265 adatsimikiziridwa pa 1.70, 2.15, ndi 1.90 Å resolution, motsatira.Inhibitor iliyonse imamangiriza ku tsamba logwira ntchito la ppCPB mofanana ndi zomwe zawonedwa kale zoletsa.Choncho, mu ma complexes, selenium, sulfure, ndi phosphinic acid oxygen imagwirizanitsa ndi zinc mu ppCPB.Uku ndiye kuwunika koyamba ndi lipoti la selenium yolumikizana ndi zinc mu CPB.