Zogulitsa

Bromelain (BR) ndi cysteine ​​​​protease yomwe imalepheretsa kutulutsa matumbo ndi kutupa.Komabe, zotsatira zake pamatumbo am'mimba sizidziwika.Choncho, tinafufuza zotsatira za mankhwala opangidwa ndi zomera izi pa mgwirizano wa matumbo ndi kuyenda kwa mbewa.Kuyenda mu vivo kunayesedwa poyesa kugawidwa kwa cholembera cha fulorosenti choyendetsedwa pakamwa m'matumbo aang'ono.Transit idawunikidwanso m'magawo a pathophysiologic oyambitsidwa ndi mafuta opangira-kutupa a croton kapena ndi diabetogenic agent streptozotocin.Bromelain adaletsa kuphatikizika komwe kumapangidwa ndi mitundu yosiyanasiyana ya spasmogenic mu mbewa ileum yokhala ndi mphamvu yofananira.Mphamvu ya antispasmodic idachepetsedwa kapena kutsutsidwa ndi proteolytic enzyme inhibitor, gabexate (15 × 10 (-6) mol L (-1)), protease-activated r eceptor-2 (PAR-2) antagonist, N (1) -3 -methylbutyryl-N(4) -6-aminohexanoyl-piperazine (10(-4) mol L(-1)), phospholipase C (PLC) inhibitor, neomycin (3 × 10(-3) mol L(-1)) , ndi phosphodiesterase 4 (PDE4) inhibitor, rolipram (10(-6) mol L(-1)).Mu vivo, BR makamaka inhibited motility m'mayiko a pathophysiologic mu njira ya PAR-2-antagonist-sensitive.Deta yathu imasonyeza kuti BR imalepheretsa kuyenda kwa m'mimba - makamaka m'matenda a pathophysiologic - ndi makina omwe amaphatikizapo nembanemba PAR-2 ​​ndi PLC ndi PDE4 monga intracellular. zizindikiro.Bromelain ikhoza kukhala chigawo chotsogolera pakupanga mankhwala atsopano, okhoza kusintha matumbo motility mu kutupa ndi matenda a shuga.