Zogulitsa

Benzyl N- [2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pofufuza mankhwala ndi chitukuko cha mankhwala.Mapangidwe ake a molekyulu amakhala ndi gulu la benzyl lomwe limalumikizidwa ndi gulu logwira ntchito la carbamate kudzera pamtundu wa piperidine. Chimodzi mwazinthu zazikulu zogwiritsira ntchito Benzyl N--[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride ndi monga choyambira. kapena wapakatikati mu kaphatikizidwe zosiyanasiyana mankhwala mankhwala.Kukhalapo kwa mphete ya piperidine kumapangitsa kuti pawiriyi ikhale yosunthika muzochitika zamagulu achilengedwe, zomwe zimapangitsa kuti zikhale zofunikira poyambira pakupanga mamolekyu osiyanasiyana ovuta.Poyambitsa kaphatikizidwe kameneka m'njira yopangira, akatswiri a zamankhwala amatha kupeza mitundu yambiri yazinthu zatsopano zomwe zingagwiritsidwe ntchito pochiza. chomangira chopangira mankhwala atsopano olunjika panjira zachilengedwe kapena zolandilira.Zomwe zimapangidwira zimapangitsa kuti zikhale zoyenera kuphatikizidwa mu mamolekyu a mankhwala, kuchita ngati pharmacophore kapena gulu lofunika kwambiri lomwe limayang'anira ntchito yomwe mukufuna.Mwa kusintha zigawo za benzyl, piperidine, kapena carbamate, ofufuza amatha kupititsa patsogolo mphamvu ya mankhwala, kusankha, ndi mankhwala a pharmacokinetic.Chigawochi chingakhalenso ngati chida kapena chidziwitso cha kafukufuku wa mankhwala opezeka mankhwala ndi mapangidwe-ntchito (SAR) maphunziro.Poyerekeza zochitika zamoyo za zotumphukira zosiyanasiyana kapena ma analogi a Benzyl N--[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride, ofufuza atha kudziwa zambiri za ubale-ntchito, kuwalola kupanga zamphamvu kwambiri. ndi mankhwala osankhidwa.Chidziwitsochi n'chofunika kwambiri pa kukhathamiritsa kwa mankhwala opangira mankhwala komanso kuti anthu azitha kugwiritsa ntchito mankhwala osokoneza bongo. Kuphatikiza apo, Benzyl N--[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ingagwiritsidwe ntchito pofufuza zachipatala. kuphunzira limagwirira ntchito ya mankhwala ena kapena kufufuza kagayidwe ka mankhwala.Pogwiritsa ntchito ma radiolabeled kapena ma tag a pawiriwa, ofufuza amatha kuyang'anira momwe amagawa komanso kagayidwe kake muzinthu zachilengedwe.Chidziwitsochi chimathandiza kumvetsetsa momwe mankhwala amapangidwira ndi kuchotsedwa m'thupi, kupereka chidziwitso chofunikira pa kuyanjana kwa mankhwala, ndondomeko ya mlingo, ndi kuyanjana kwa mankhwala osokoneza bongo.Mwachidule, Benzyl N--[2-(piperidin-4-yl) propan- 2-yl]carbamate hydrochloride ndi chinthu chosunthika chomwe chimagwiritsidwa ntchito kwambiri pofufuza zamankhwala komanso kupanga mankhwala.Mapangidwe ake amapangidwira kukhala ofunika ngati kalambulabwalo wa kaphatikizidwe kamitundu yosiyanasiyana yamankhwala komanso ngati chomangira chopangira mankhwala atsopano.Kuphatikiza apo, imagwira ntchito ngati chida chamaphunziro a SAR, kupezeka kwa mankhwala osokoneza bongo, komanso kafukufuku wa metabolism.Kugwiritsa ntchito kosiyanasiyana kwa Benzyl N- [2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride kumawonetsa kufunikira kwake pakupanga zida zatsopano zochizira komanso kupita patsogolo kwa chemistry yamankhwala.