Zogulitsa

Kunenepa kwambiri, matenda a shuga a mtundu wa 2 ndi hyperlipidemia nthawi zambiri zimakhala pamodzi ndipo zimalumikizidwa ndi kuchulukirachulukira kwakufa komanso kufa.Kugwiritsiridwa ntchito kwa ma carbohydrate oyeretsedwa makamaka fructose kwakula kwambiri m'zaka zaposachedwa ndipo kwafanana ndi kuchuluka kwa kunenepa kwambiri komanso matenda a shuga.Kafukufuku wa anthu ndi nyama awonetsa kuti kudya kwambiri kwa fructose kumayenderana ndi kuchuluka kwa dyslipidemia, kukana insulini, ndi matenda oopsa.Metabolism ya fructose imapezeka makamaka m'chiwindi ndipo kuchuluka kwa fructose kumabweretsa kuwonjezeka kwa hepatic triglyceride (hepatic steatosis).Izi zimabweretsa kusokonezeka kwa glucose ndi lipid metabolism komanso kuwonjezeka kwa proinflammatory cytokine expression.Apa tikuwonetsa kuti fructose imasintha mawu olimbikitsa shuga a activated acetyl CoA carboxylase (ACC), pSer hormone sensitive lipase (pSerHSL) ndi adipose triglyceride lipase (ATGL) mu hepatic HepG2 kapena primary hepatic cell cultures in vitro.Izi zidalumikizidwa ndi kuchuluka kwa de novo triglyceride kaphatikizidwe mu vitro ndi hepatic steatosis mu vivo mu fructose motsutsana ndi glucose-omwe amadyetsedwa komanso mbewa zodyetsedwa wamba.Maphunzirowa amapereka chidziwitso chatsopano cha njira zomwe zimakhudzidwa ndi fructose-mediated hepatic hypertriglyceridemia ndikuzindikira kuti fructose-uptake ndi njira yatsopano yochizira matenda okhudzana ndi lipid.