Zogulitsa

Gelisi ya Chitosan-dextran yakhala ikugwiritsidwa ntchito ngati antihemostatic agent ndi antiadhesive agent pambuyo pa opaleshoni ya endoscopic sinus.Chifukwa Staphylococcus aureus biofilms akhala akukhudzidwa ndi recalcitrant chronic rhinosinusitis, kafukufukuyu cholinga chake ndi kufufuza mopitilira (i) anti-inflammatory, (ii) bacterial biofilm inhibition, (iii) antiproliferative effect, ndi (iv) machiritso a chitosan ndi Chitosan-dextran gel. Fibroblasts anali olekanitsidwa ndi minofu ya mphuno ya munthu ndipo amagwiritsidwa ntchito kuti adziwe zotsatira za gel osakaniza chitosan ndi chitosan-dextran pa (i) kuchuluka kwa maselo, (ii) machiritso a bala, (iii) kutupa kwa chikhalidwe cha fibroblast chotsutsidwa ndi superantigens S. aureus enterotoxin B (SEB) ndi toxic shock syndrome toxin (TSST), ndi (iv) pa S. aureus biofilms.Chitosan inali yothandiza kwambiri kuchepetsa mawu a IL-8 pambuyo pa vuto la TSST ndi SEB.Chitosan inalinso yothandiza pochepetsa IL-8 mawu a fibroblasts osatsutsika omwe akuwonetsa zotsatira zake zotsutsana ndi zotupa pa ma fibroblasts m'malo otsatsa.Gelisi ya Chitosan-dextran inasonyeza mphamvu za antibiofilm pa 50% (v/v) concentration in vitro.Dextran, payokha, adawonetsa katundu wa antibiofilm pa 1.25% (w / v) ndende.Chitosan, payokha, idachepetsa kuchuluka kwa ma fibroblasts mpaka 82% ya kuwongolera kuchulukana komanso gel osakaniza a chitosan-dextran adachepetsa kuchuluka kwa fibroblasts mpaka 0.04% ya kuwongolera kuchuluka.Mogwirizana ndi zowongolera zopanda chithandizo, gelisi ya chitosan-dextran idachedwetsa kwambiri machiritso a mabala pa maola oyambirira a 48 a kuyesera. Gelisi ya Chitosan-dextran inachepetsa kuchuluka kwa fibroblast ndi nthawi yochiritsa mabala, kusonyeza njira yotheka yochepetsera zomatira pambuyo pa opaleshoni. nthawi.Chitosan adachepetsa milingo ya IL-8, kuwonetsa anti-inflammatory properties.Gelisi ya Chitosan-dextran ndi chithandizo cha dextran chinasonyeza mphamvu za antibiofilm mu chitsanzo chathu.