Albendazole Cas: 54965-21-8
| Nambala ya Catalog | XD91873 |
| Dzina lazogulitsa | Albendazole |
| CAS | 54965-21-8 |
| Fomu ya Molecularla | Chithunzi cha C12H15N3O2S |
| Kulemera kwa Maselo | 265.33 |
| Zambiri Zosungira | 2-8 ° C |
| Harmonize Tariff Code | 29332990 |
Mafotokozedwe a Zamalonda
| Maonekedwe | White crystalline ufa |
| Asay | 99% mphindi |
| Malo osungunuka | 208-210 ° C |
| kachulukidwe | 1.2561 (kuyerekeza movutikira) |
| refractive index | 1.6740 (chiyerekezo) |
| kusungunuka | Pafupifupi osasungunuka m'madzi, osungunuka bwino mu anhydrous formic acid, osungunuka pang'ono mu methylene chloride, pafupifupi osasungunuka mu Mowa (96 peresenti). |
| pka | 10.72±0.10 (Zonenedweratu) |
| Kusungunuka kwamadzi | 0.75mg/L(209 ºC) |
Albendazole ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda omwe amayamba chifukwa cha tizilombo toyambitsa matenda.Itha kuperekedwa pochiza matenda osowa muubongo (neurocysticercosis) kapena ingaperekedwe pochiza matenda a parasitic omwe amayambitsa kutsekula m'mimba kofunikira (microsporidiosis).
Chochokera ku benzimidazole, albendazole ndi mankhwala okhala ndi antihelmintic spectrum.Imawonetsa antihelmintic effect motsutsana ndi cestodes ndi nematodes tcheru mwa kutsekereza njira ya glucose kutengeka ndi tizilombo toyambitsa matenda, zomwe zimasonyezedwa mu kuchepa kwa nkhokwe za glycogen ndi kuchepetsa kuchepa kwa adenosintriphophate.Chifukwa cha zimenezi, tizilomboti timasiya kuyenda n’kufa.Amagwiritsidwa ntchito pa matenda a Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, ndi Trichuris trichiura.Mafananidwe a mankhwalawa ndi SKF 62979 ndi ena.
Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole,Zentel) ndi mankhwala anthelmintic omwe sakugulitsidwa pano ku North America.Imapezeka kuchokera kwa wopanga pogwiritsa ntchito mwachifundo.Albendazole amagwiritsidwa ntchito kwambiri padziko lonse lapansi pochiza matenda a intestinalnematode.Ndiwothandiza ngati mankhwala amtundu umodzi wa ascariasis, matenda a Hookworm a New and Old World, ndi trichuriasis.Angapo mlingo mankhwala ndi albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, ndi matenda hydatid.Mphamvu ya albendazole motsutsana ndi nyongolotsi (cestodes) nthawi zambiri imakhala yosinthika komanso yosasangalatsa.
Albendazole imapezeka ngati ufa woyera wa crystalline womwe susungunuka m'madzi.The m`kamwa mayamwidwe albendazoleis kumatheka ndi mafuta chakudya.Mankhwalawa amapita mofulumira komanso kagayidwe kake kamene kamayambitsa sulfoxide, yomwe ndi mawonekedwe a plasma.Kuchotsa theka la moyo wa sulfoxide kumachokera ku maola 10 mpaka 15.Kuchuluka kwa biliary excretion ndi enterohepatic recycling ya albendazolesulfoxide kumachitika.Albendazole nthawi zambiri amalekerera mulingo umodzi wamankhwala a m'mimba nematodes.Mlingo waukulu, chithandizo chanthawi yayitali chomwe chimafunikira chithandizo cha matenda a clonorchiasis orechinococcal kungayambitse zotsatira zoyipa monga kupsinjika kwa mafupa, kukwera kwa michere ya chiwindi, ndi alopecia.
Albendazole ali yotakata sipekitiramu ntchito motsutsana matumbo nematodes ndi cestodes, komanso chiwindi flukes Opisthorchis sinensis, Opisthorchis viverrini, ndi Clonorchis sinensis.Yagwiritsidwanso ntchito bwino motsutsana ndi Giardia lamblia.Albendazole ndi mankhwala othandiza hydatid chotupa matenda (echinococcosis), makamaka limodzi ndi praziquantel.Zimathandizanso pochiza matenda a ubongo ndi msana, makamaka akaperekedwa ndi dexamethasone.Albendazole akulimbikitsidwa kuchiza gnathostomiasis.
