Zogulitsa

Ma metallointercalators khumi ndi asanu a platinamu(II) apangidwa omwe amagwiritsa ntchito 1,10-phenanthroline (phen) ligands, kuphatikiza 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) ndi dipyrido[3,2-d :2',3'-f]quinoxaline (dpq), and achiral ethylenediamine (en) and the chiral ancillary ligands 1S,2S-diaminocyclohexane (S,S-dach) and 1R,2R-diaminocyclohexane (R,R-dach) .Cytotoxicity yawo mu L1210 murine leukemia cell line idatsimikiziridwa pogwiritsa ntchito njira zoletsa kukula.Mitundu yambiri yachitsulo ya cytotoxic ndi yomwe ili ndi S,S-dach ancillary ligands ndi 5-CH3-phen intercalating ligands.Metallointercalator imodzi [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), imasonyeza kuwonjezeka kwa 5-10 kwa cytotoxicity poyerekeza ndi cisplatin wothandizira chipatala.Kuchokera pakuyesa komanga kwa DNA zikuwoneka kuti palibe kusiyana kwakukulu pakati pa zitsulo zilizonse, zomwe zikuwonetsa kuti palibe DNA yomangiriza kuyanjana kapena njira yomangirira / DNA adduct yomwe imapangidwa ndizomwe zimatsimikizira kuti cytotoxicity ya banja ili la platinamu(II)-based metallointercalators.