Zogulitsa

(4R-Cis) -1,1-Dimethylethyl-6-[2--[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4--[(phenylamino)carbonyl]-1H-pyrrol -1-yl] ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate ndi mankhwala omwe ali ndi mankhwala ovuta.Ngakhale kuti chidziwitso chodziwika bwino chogwiritsira ntchito mankhwalawa chikhoza kukhala chochepa, tikhoza kukambirana za momwe angagwiritsire ntchito potengera mawonekedwe ake komanso makhalidwe omwe amafanana nawo. monga solubilizing wothandizira.Dioxane ndi chosungunulira wamba, makamaka mu organic chemistry, chifukwa ndi yosakanikirana ndi madzi ndipo imakhala ndi kusungunuka kwabwino kwa mamolekyu osiyanasiyana.Kukhalapo kwa dioxane moiety m'gululi kumasonyeza kuti akhoza kukhala ndi mphamvu zosungunuka zofanana. Komanso, zigawo zamagulu amtunduwu, monga magulu a fluorophenyl ndi phenylamino carbonyl, zimasonyeza zomwe zingatheke.Kulowa m'malo mwa fluorine muzinthu zachilengedwe kumatha kukulitsa mphamvu zawo za pharmacokinetic, zomwe zitha kukulitsa mphamvu zawo kapena bioavailability.Kukhalapo kwa gulu la phenylamino carbonyl kungasonyeze kuthekera kwa kugwirizana ndi zolinga zamoyo, zomwe zingathe kutsogolera ku zotsatira zochiritsira.Kutengera mawonekedwe apangidwe awa, ndizotheka kuti pawiriyi ikhoza kukhala ndi ntchito mu chemistry yamankhwala kapena chitukuko cha mankhwala.Ikhoza kufufuzidwa ngati chigawo chothandizira kupanga mankhwala atsopano okhudzana ndi matenda enaake.Komabe, ndikofunikira kuzindikira kuti maphunziro owonjezera akufunika kuti adziwe momwe zinthu zilili zenizeni, kuphatikiza mphamvu zake, momwe zimagwirira ntchito, komanso zotsatirapo zake. Kuphatikiza pa chemistry yamankhwala, nitronyl kapena pyrrole moiety yamtunduwu imatha kuwonetsa kugwiritsa ntchito sayansi yazinthu. kapena ngati chigawo cha mankhwala synthesis.Zotulutsa za Nitronyl ndi pyrrole zafufuzidwa kuti zitha kugwiritsidwa ntchito ngati ma organic conductors, catalysts, kapena zomangira zomangira zovuta.Komabe, mapulogalamuwa adzafunika kufufuza kwina ndi kukhathamiritsa kwa njira zophatikizira. methylethyl) -3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate imasonyeza kuthekera kwa ntchito mu chemistry yamankhwala, sayansi ya zinthu, kapena kaphatikizidwe ka mankhwala.Komabe, ndikofunikira kuti tifufuze mozama kuti tiwunikire katundu wake, kupanga njira zoyenera zophatikizira, ndikuzindikira momwe angagwiritsire ntchito gawo lililonse.