Zogulitsa

4-Chloro-2-fluoro-3-methoxyphenylboronic acid ndi mankhwala omwe ali ndi ntchito zosiyanasiyana mu organic synthesis, chemistry yamankhwala, ndi sayansi yazinthu. mu kusintha kwachitsulo-catalyzed cross-coupling reactions.Imagwira ntchito ngati chomangira cha boronic acid, chomwe chimalola kupanga mapangidwe a carbon-carbon kapena carbon-heteroatom bond.Mwachitsanzo, mankhwalawa amatha kugwiritsidwa ntchito polumikizana ndi Suzuki-Miyaura, pomwe amakumana ndi aryl kapena vinyl halide pansi pa palladium catalysis kuti apange mankhwala a biaryl.Kuphatikizika kumeneku kumagwiritsidwa ntchito kwambiri popanga mamolekyu ovuta a organic, kuphatikiza mankhwala ndi agrochemicals, komanso kupanga zinthu zachilengedwe.Kuphatikizika kwapadera kwamagulu a chlorine, fluorine, ndi methoxy mu kapangidwe ka 4-Chloro-2 -fluoro-3-methoxyphenylboronic asidi chimathandiza synthesis zosiyanasiyana zotumphukira ndi ogwirizana katundu.Atomu ya klorini ikhoza kukhala gulu lotsogolera mu kusintha kwachitsulo-catalyzed process, kuwongolera zomwe zimasankhidwa kumalo enaake mkati mwa molekyulu.Kulowetsedwa kwa Fluorine kumapereka lipophilicity yowonjezereka, yomwe ingakhudze mphamvu ya pharmacokinetic ya pharmacokinetic ndikuwongolera bioavailability yake.Gulu la methoxy, kumbali inayo, likhoza kukhala ngati gulu loteteza kapena kutenga nawo mbali pakusintha kwa mankhwala osiyanasiyana.Mu chemistry yamankhwala, 4-Chloro-2-fluoro-3-methoxyphenylboronic acid ndi zotumphukira zake zimakhala ndi chidwi ngati ofuna mankhwala.Magulu ogwira ntchito monga chlorine ndi fluorine amatha kusinthira kuyanjana kwapawiri ndi zolinga zachilengedwe ndikuwongolera mphamvu zake zamankhwala.Kuphatikiza apo, gulu la methoxy limatha kukulitsa kukhazikika kwa kagayidwe kazakudya ndikuthandizira kuti lipophilicity ndi kusungunuka kwake.Zinthu izi zimapangitsa 4-Chloro-2-fluoro-3-methoxyphenylboronic acid kukhala poyambira kofunikira popanga zida zatsopano zochizira m'magawo monga oncology, matenda opatsirana, komanso kutupa. -3-methoxyphenylboronic acid imatha kupanga ma esters okhazikika a boronate, omwe amagwiritsidwa ntchito popanga zinthu zomwe zili ndi zinthu zapadera.Zidazi zimatha kuwonetsa mawonekedwe owoneka bwino, zamagetsi, kapena othandizira, kutengera kapangidwe kake ndi kapangidwe kake.Kuphatikizika kwa 4-Chloro-2-fluoro-3-methoxyphenylboronic acid kapena zotumphukira zake muzinthu izi zitha kupatsa magwiridwe antchito apadera ndikuwongolera magwiridwe antchito awo. chifukwa cha chemistry yake yosunthika komanso kuthekera kopanga mamolekyu ogwira ntchito ndi zida.Udindo wake pakusintha kwazitsulo zolumikizidwa ndi zitsulo, kuphatikiza ndi mawonekedwe apadera amagulu ake ogwira ntchito, zimapangitsa kukhala chida chamtengo wapatali mu kaphatikizidwe ka organic ndi chemistry yamankhwala.Kuphatikiza apo, boronic acid moiety imathandizira kupanga ma esters a boronate, omwe amathandizira pakupanga zinthu zapamwamba zokhala ndi zida zogwirizana.