Zogulitsa

(3S) -3- [4- [(5-Bromo-2-chlorophenyl) methyl]phenoxy]tetrahydrofuran ndi mankhwala omwe ali m'gulu la zotumphukira za tetrahydrofuran.Amagwiritsidwa ntchito popanga kafukufuku wamankhwala ndi chitukuko chifukwa cha mphamvu zake zochiritsira. Chimodzi mwazofunikira kwambiri pagululi ndi kuthekera kwake kolumikizana ndi zolandilira zosiyanasiyana zamoyo, michere, kapena mapuloteni m'thupi la munthu.Kuyanjana kumeneku kungayambitse kusinthika kwa njira zinazake zam'magazi, zomwe zimapangitsa kuti pakhale zotsatira zochiritsira.Ofufuza nthawi zambiri amafufuza ntchito ya pawiri ngati mankhwala omwe angakhalepo pa matenda osiyanasiyana.Zomwe zimapangidwira, kuphatikizapo kukhalapo kwa mphete ya tetrahydrofuran ndi gulu la phenyl lolowa m'malo, zimathandiza kuti pakhale mankhwala ake apadera.Gulu la phenyl limapereka kuyanjana kwa hydrophobic, zomwe zingakhudze kusungunuka kwa pawiri ndi kumangiriza kuyanjana kwa mapuloteni.Kuonjezera apo, kukhalapo kwa maatomu a bromine ndi klorini mu mphete ya phenyl kumawonjezera kusinthasintha kwa mankhwala a pawiri, zomwe zimapangitsa kuti pakhale kuyanjana kwapadera ndi mamolekyu omwe amawaganizira. -Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran kupita ku zolandilira kapena ma enzymes kudziwa momwe angachiritsire.Chifukwa chake, ochita kafukufuku amafufuza zotsatira zake pazinthu zosiyanasiyana zamagulu, monga zolandilira zomwe zimakhudzidwa ndi kutupa, khansa, kapena matenda apakati a mitsempha.Mayesero osiyanasiyana achilengedwe ndi mitundu ya nyama angagwiritsidwe ntchito kuti adziwe momwe zimagwirira ntchito, kuyamwa, kugawa, kagayidwe, ndi katulutsidwe.Izi ndizofunikira pakuwunika mankhwala a pharmacokinetics ndikumvetsetsa momwe zimagwirira ntchito ndi thupi la munthu. idakali mu gawo la kafukufuku, ndipo njira zake zochiritsira zomwe zingagwiritsidwe ntchito sizinafufuzidwe mokwanira.Maphunziro ochuluka, kuphatikizapo mayesero a zachipatala mwa anthu, angafunike kuti adziwe chitetezo chake ndi mphamvu zake zisanaganizidwe kuti zigwiritsidwe ntchito pochiza. ]phenoxy]tetrahydrofuran pakali pano ikufufuzidwa chifukwa cha mankhwala omwe angakhale nawo pa kafukufuku wamankhwala.Kapangidwe kake kapadera ka mankhwala kumathandizira kuti pakhale kuyanjana kwake ndi zolinga zenizeni zamoyo, ndikutsegula mwayi wopanga zida zatsopano zochizira.Komabe, kufufuza kwina ndi kuunika ndikofunikira kuti mudziwe kuthekera kwake kwenikweni ngati mankhwala ochiritsira.