Zogulitsa

(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, yomwe imadziwikanso kuti TBDMS-protected tetrahydro-2H-pyran -2-imodzi, ndi mankhwala omwe amagwiritsidwa ntchito kwambiri popanga organic synthesis komanso ngati gulu loteteza m'munda wa chemistry.Mmodzi wofunika kwambiri wa TBDMS-protected tetrahydro-2H-pyran-2-imodzi ndi ntchito yake monga chomangira mu kaphatikizidwe. za mamolekyu ovuta.Kampaniyi ili ndi malo angapo osinthika omwe amatha kusintha magawo osiyanasiyana ogwira ntchito.Gulu loteteza la TBDMS (tert-butyldimethylsilyl) lomwe lili mu molekyulu limapereka bata ndikulola kusinthidwa kosankhidwa kwamagulu enaake ogwira ntchito.Kusinthasintha kumeneku kumapangitsa TBDMS-protected tetrahydro-2H-pyran-2-imodzi kukhala yapakatikati yofunikira pakupanga zinthu zachilengedwe, mankhwala, ndi mankhwala ena abwino.Kugwiritsanso ntchito kwina kwa TBDMS-protected tetrahydro-2H-pyran-2-one udindo ngati gulu loteteza ma alcohols ndi ma amines mu organic synthesis.Gulu la TBDMS litha kuwonjezeredwa kumagulu a hydroxyl kapena amino, kuwaphimba bwino pamachitidwe osiyanasiyana.Chitetezo ichi chimalepheretsa zochitika zam'mbali zosafunikira ndikuwonetsetsa kuti masinthidwe omwe akufuna kuchitika pamasamba omwe mukufuna.Zomwe zimafunidwa zikatha, gulu la TBDMS likhoza kuchotsedwa mosavuta, kuwonetsa gulu loyambirira la hydroxyl kapena amino popanda kukhudza ntchito zina mu molekyulu.TBDMS-protected tetrahydro-2H-pyran-2-one imapezanso ntchito ngati wothandizira wotetezera chakudya.Amalola chitetezo chosankhidwa chamagulu a hydroxyl mu mamolekyu a shuga panthawi ya glycosylation, ndikupangitsa kuti ma glycans ovuta ndi glycosides apangidwe.Njira yotetezerayi ndi yofunika kwambiri mu chemistry ya carbohydrate, kumene magulu angapo a hydroxyl alipo ndipo regioselectivity yeniyeni imafunikanso.Chophatikizikacho chikhoza kuphatikizidwa m'mapangidwe a polima, ndikupatsanso malo osinthika kuti asinthenso komanso momwe amalumikizirana.Izi zimathandizira kupanga zida za polima zomwe zimakhala ndi zida zofananira komanso magwiridwe antchito, monga kukhazikika bwino, kukhazikika kwachilengedwe, komanso kutulutsidwa kwamankhwala oyendetsedwa bwino.Pomaliza, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6 -((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, kapena TBDMS-protected tetrahydro-2H-pyran-2-one, ndi gulu losunthika lomwe limagwiritsidwa ntchito mosiyanasiyana mu kaphatikizidwe ka organic, makamaka ngati chomangira ndi gulu loteteza. .Kuthekera kwake posankha kuteteza magulu ogwira ntchito komanso kuthandizira kusintha kwa mamolekyu kumapangitsa kukhala chida chamtengo wapatali pazamankhwala.Kufufuza kopitilira muyeso ndikuwunika momwe amagwiritsidwira ntchito kungavumbulutsenso ntchito zina ndikuthandizira kupita patsogolo kwa chemistry yopanga ndi sayansi yazinthu.