Zogulitsa

Acetoxy Empagliflozin, yomwe imadziwikanso kuti empagliflozin acetate, ndi mtundu wosinthidwa wa mankhwala a antidiabetic empagliflozin.Empagliflozin ndi m'gulu la mankhwala omwe amadziwika kuti sodium-glucose co-transporter 2 (SGLT2) inhibitors, omwe amagwiritsidwa ntchito makamaka poyang'anira matenda a shuga a 2.Poletsa mapuloteniwa, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ndi mankhwala ovuta dzina lalitali la mankhwala.Imagwera pansi pa gulu la triMethylsilyloxy pyranones, zomwe zimagwiritsidwa ntchito kwambiri pazinthu zosiyanasiyana zasayansi ndi mafakitale. Chimodzi mwazinthu zofunikira kwambiri za (3R, 4S, 5R, 6R) -3,4,5-tris(triMethylsilyloxy) -6-( (triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ndi gulu loteteza mu organic synthesis.Magulu oteteza ndi magulu osakhalitsa omwe amagwiritsidwa ntchito kuteteza malo enaake okhazikika pa molekyulu panthawi yamankhwala.Pankhani ya (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, magulu a triMethylsilyloxy amachita ngati zigawo zoteteza. .Pochitapo kanthu, maguluwa amateteza magulu ena ogwira ntchito kuti asakumane ndi zosayenera, zomwe zimalola kuti zomwe akufunazo ziyende bwino.Zomwe zimachitikazo zikatha, magulu a triMethylsilyloxy akhoza kuchotsedwa mosavuta, kuwulula magulu oyambirira a ntchito. Methyl) tetrahydro-2H-pyran-2-one ili mu kaphatikizidwe ka organic mankhwala.Itha kugwiritsidwa ntchito ngati chomangira chomangira zinthu zovuta kwambiri.Kapangidwe kake kapadera ka mankhwala ndi reactivity kumapangitsa kukhala chida chofunikira pakupanga zinthu zatsopano zamakina.Akatswiri a zamankhwala amatha kugwiritsa ntchito (3R, 4S, 5R, 6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one kuti adziwe magulu enaake ogwira ntchito kapena kupanga maselo enieni. scaffolds kuti aphunzire zochitika zachilengedwe za mankhwala kapena kupanga mankhwala atsopano.Kuonjezera apo, mankhwalawa angapeze ntchito mu sayansi ya zinthu.Kukhalapo kwake ngati gulu logwira ntchito mu molekyulu kungapereke zinthu zina zofunika ku zipangizo.Mwachitsanzo, ikhoza kuonjezera kusungunuka kwa zosungunulira zinazake kapena kusintha mawonekedwe opanga mafilimu, kupangitsa kuti ikhale yothandiza popaka kapena zomatira.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-(( triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ndi gulu lapadera lomwe limagwiritsidwa ntchito mosiyanasiyana m'magawo osiyanasiyana asayansi ndi mafakitale.Kukhoza kwake kukhala gulu loteteza ndikukhala ngati chomangira mu chemistry yopanga, komanso momwe angagwiritsire ntchito mu sayansi ya zinthu, kumapangitsa kuti ikhale yofunika kwambiri pakupanga mamolekyu atsopano ndi zipangizo.Komabe, kagwiritsidwe ntchito kake kolondola komanso kagwiritsidwe ntchito kake kumatha kusiyanasiyana, kutengera zofunikira ndi zolinga za polojekiti inayake yasayansi kapena mafakitale.